Anticoagulants Flashcards
MOA of unfractionated heparin
Complex with AT and inhibits mainly factors Xa and IIa.
MOA of low mw heparin
Complex with AT and inhibits factors Xa and IIa-Monitored by anti-Xa
MOA of Fondaparinux
Complex with AT and inhibits factor Xa
MOA of argatroban
Directly Inhibits IIa, liver excretion, short t1/2
MOA of bivalirudin
Directly Inhibits IIa, renal excretion, short t1/2
MOA of hirudin
Directly Inhibits IIa, no cofactor, renal excretion, short t1/2
MOA of antithrombin concentrate
directly inhibits IIa
MOA of protamine sulfate
heparin antagonist
MOA of warfarin
Competitive antagonist of vitamin K. Suppresses the synthesis of functional forms of factors II, VII, IX and X by blocking enzyme epoxide reductase in liver
MOA of Vitamin K
Cofactor in the synthesis of functional forms of factors II, VII, IX and X
MOA of
Oral Anti-Xa:
Rivaroxaban (R)
Apixaban (A)
Edoxaban (E)
Inhibits factor Xa
MOA of Oral Antithrombin Dabigatran
Inhibits thrombin
Route of Admin- unfractionated heparin
Mainly intravenous and also given subcutaneous
Route of Admin- LMW heparin and fondaparinux
Subcutaneous
Route of Admin- argatroban, bivalirudin, hirudin, antithrombin concentrate, protamine sulfate
IV