LMND

Question 1

discuss spinal muscular atrophy

Answer 1

hereditary degeneration of LMN

weakness and atrophy of skeletal muscles

Question 2

clinical features of spinal muscular atrophy

Answer 2

proximal weakness >

hypo/areflexia

fasciculation of tongue

hand tremor

normal sensory and changes in EMG

SMA1: death by 2 yo
SMA2: alive until 20 but cant walk

Question 3

discuss hereditary sensory motor nueropathy

Answer 3

peroneals and distal leg atrophy

weakness

sensory loss

areflexia

Question 4

discuss poliomyelitis

Answer 4

damage to ant horn cell d/t poliovirus via fecal-oral

fever, malaise, myalgia, sore throat, GI

assym weakness and atrophy of LE> –> flaccid paralysis

Question 5

types of polio

Answer 5

type 1: brunhilde - MC

type 2: lansing

type 3: leon

Question 6

acute stage of polio

Answer 6

1-6 wks

peak fever in 3rd day

assym paralysis of LE>UE
cold intolerance
back-knee, ant trunk lean or foot drop gait

Question 7

convalescent/recovery stage of polio

Answer 7

6 wks-6 mo

Question 8

convalescent/recovery of strength monitored stage of polio

Answer 8

w/in 6 wks

Question 9

residual/chronic stage of polio

Answer 9

> 6 mo

weakness, atrophy, limb shortening, postural and gait deformity

Question 10

discuss post-polio syndrome

Answer 10

stable for 15 years p polio

onset of 2 or more for atleast 1 yr:
new weakness
new atrophy
dec endurance
muscle and joint pain
cold intolerance
functional loss