Liverdisorders

Question 1

Cholestasis is defined by what?? What does it cause as a result

Answer 1

Impaired bile formation or flow - fatigue,pruritus,dark urine,pale,jaundice

Question 2

Cholestatic pruritus:
Can be relived using what???

Answer 2

• Can be relived by cholestryamine,ursodeoxycholic acid and Rifampicin

Question 3

Intrahepatic cholestasis in pregnancy:
Can occur during which trimester? What outcomes does it have? Treated with???

Answer 3

• During late pregnancy - adverse fatal outcomes
  
  • Treatment with pruritus associated - ursodeoxycholic acid

Question 4

Gallstones are what? Where are they formed and what are the majority of patients??

Answer 4

Hard mineral or fatty deposits forming stones in the gallbladder bile duct

- Majority of patients are asymptomatic 
- Irritated/blocked gallbladder - pain,infection and inflammation

Question 5

Untreated choelistasis can lead to what? What would happen if symptoms develop? What is the drug treatment?? For mild/mod vs severe

Answer 5

It can lead to - biliary colic,cholecystitis,pancreatitis
- If symptoms develop - surgically removed
- Drug treatment =
- Mild to moderate pain:paracetamol or NSAID
- Severe pain:IM diclofenac