Liver Structure and Function Flashcards

1
Q

What are the four lobes of the liver

A

Riht, left,caudate,quadrate

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2
Q

What is the nerve supply of the liver

A

The hepatic plexus which contains sympathetic (from the coeliac plexus) and parasympathetic (from the vagus nerve) all via porta on inferior surface

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3
Q

The caudate lobe is located:

A

on the visceral surface between the IVC and a fossa formed by ligamentum venosum

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4
Q

The quadrate lobe is located:

A

between gallbladder and a fossa formed by the ligamentum teres

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5
Q

What does the porta hepatis not transmit

A

Hepatic veins

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6
Q

What is the liver covered by

A

A connective tissue (Glisson’s) capsule and visceral peritoneum except at the bare area (small area on diaphragmatic surface surrounded by coronary ligament)

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7
Q

What divides liver hepatocytes into hexagonal lobules

A

Septa

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8
Q

What is the portal triad

A

The hepatic artery,portal vein and hepatic duct. They’re located at the corner of each hexagonal lobule

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9
Q

What do the central veins branch to

A

Hepatic veins that branch into the IVC

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10
Q

What are hepatic cords made out of

A

Hepatocytes

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11
Q

What are the blood channels bw hepatic cords

A

Hepatic sinusoids

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12
Q

Where do cannaliculi lead to

A

Hepatic ducts

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13
Q

What is the alimentary role of liver?

A

Production and secretion of bile

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14
Q

What are the six components of bile

A
Bile acids
Lecithin 
Cholesterol 
Bile pigments (Bilrubin)
Toxic metals 
Bicarbonate (Secreted by duct cells)
(All of the rest secreted by hepatocytes)
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15
Q

What are bile pigments

A

Breakdown products of haemoglobin from old/damaged erythrocytes

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16
Q

What gives bile its yellow colour

A

Bilrubin (extracted from blood by hepatocytes and secreted into bile)

17
Q

How does bilrubin turn brown?

A

modified by bacterial enzymes

18
Q

what colour is reabsorbed bilrubin excreted in urine

A

yellow

19
Q

What are bile acids synthesised from?

A

cholesterol in liver

20
Q

What happens to bile acids before secretion

A

Conjugated with glycine or taurine to increase solubility

21
Q

How are bile salts recycled

A

via enterohepatic circulation

22
Q

What are the three layers in the gallbladder

A

Mucosa (rugae)
Muscularis (smooth muscle)
Serosa (Connective tissue)

23
Q

What ducts does the gallbladder empty into

A

Cystic duct then common bile duct

24
Q

WHen sphincter of oddi is closed, what happens to bile

A

Forced back to gallbladder where it is concentrated by 5-20 times

25
Q

What does fat in duodenum trigger

A

Release of CCK

26
Q

What does CCK cause

A

Sphincter of Oddi relaxes Gallbladder contracts

27
Q

After fat is solubilised in duodenum CCK released even more and this causes?

A

pancreatic enzyme secretion and bile secretion