Liver Profile Flashcards
Plasma concentration is increased with what 3 things?
Hemolytic anemia
inflamed hepatocytes
Gilbert disease
What disease has all standard liver tests are within reference range, Bilirubin is elevated, and 90% or more of it is unconjugated?
Gilbert Disease
What will increase plasma conjugated bilirubin?
Obstruction to the flow of bile
Where in the body does bilirubin become urobilinogen?
Small Intestine
How much of urobilinogen is secreted in the feces?
90%
How much of urobilinogen is reabsorbed in the enterohepatic circulation and re-enters bile as conjugated bilirubin?
10%
When is Urobilinogen increased in the urine?
hemolysis
hepatitis
constipation
What do the levels of bilirubin have to be in order for the patient to present with jaundice?
> 2.5mg/dl
How much do AST plasma levels elevate with liver inflammation?
10x
What is more specific and less sensitive to liver inflammation/damage, ALT or AST?
ALT
T/F: ALT is used to confirm the liver source of an AST elevation
True
What Is the only enzyme in the Liver Profile that is specific to the Liver?
GGTP
What is GGTP also elevated with?
Alcohol consumption
What is elevated with the Hepatocellular pattern?
strong AST/ALT
mild ALP and GGTP
What is elevated with the Cholestatic pattern?
strong ALP and GGTP
mild AST/ALT
