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Clinical Lab Diagnosis > Coagulation > Flashcards

Coagulation Flashcards

1
Q

What tests for a clot, and are PROLONGED when ABNORMAL?

A

PT and PTT

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2
Q

What does PT and PTT stand for?

A

PT: Prothrombin Time
PTT: Partial Thromboplastin Time

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3
Q

What indicates decreased or dysfunctional fibrinogen?

A

Functional Fibrinogen assay

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4
Q

What shows excessive clotting breakdown products?

A

D-Dimers

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5
Q

What is the International Normalized Ratio calculated from?

A

PT

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6
Q

What are collected in Blue top, sodium citrate tubes?

A

PT and aPTT

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7
Q

What coagulation classic form pathway is the PTT test and contains factors 12, 11, 10, 9, 8

A

Intrinsic Pathway (PTT pathway)

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8
Q

What coagulation classic form pathway is the PT test and tests factor 3, 7 to 7a?

A

Extrinsic Pathway (PT) pathway

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9
Q

What coagulation classic form pathway tests for X to Xa, cleaves Prothrombin to create Thrombin IIa, and Thrombin cleaves Fibrinogen to Fibrin Ia and XIII and XIIIa?

A

Common Pathway

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10
Q

What pathway is longer?

A

Intrinsic Pathway (PTT pathway)

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11
Q

What factor is a cofactor for factor X?

A

Factor V

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12
Q

What condition has a deficiency of factor 8 and has increase in PTT but not PT?

A

Hemophilia A

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13
Q

What condition affects 2, 7, 9, 10, mainly increasing PT?

A

Vit K Deficiency

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14
Q

What condition affects factor 9 deficiency and has an increase in the aPTT?

A

Hemophilia B (Christmas Disease)

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15
Q

What condition defiency of vonWillebrand Factor, (carries VIII), prolongs aPTT, decreases platelet aggregometry?

A

vonWillebrand’s Disease

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16
Q

What deficiency is very rare, would prolong aPTT, PT, and be demonstrated on Functional Fibrinogen Assay?

A

Fibrinogen deficiency

17
Q

What disease would affect most factors except III (tissue factor), IV (calcium ions), and VIII (because VIII is also produced by endothelial cells), affecting aPTT and PT?

A

Severe Liver Disease

18
Q

What antiphospholipid autoantibody that causes INCREASED clotting (it was named due to an IN VITRO effect); only 50% of folks with this antibody have lupus. Associated with repeated first trimester miscarriages?

A

Lupus Anticoagulant

Clinical Lab Diagnosis (10 decks)

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