Liver Pathology Flashcards
Abnormal retention of lipids
Steatosis
In the general pathological process stress is created whenever there is the change in
If the source of stress is not removed what will happen
Environment internally or externally
Cell will go through degenerative changes eventually death
What happens during cellular adaptions
Changes the cell makes in order to adjust to stress
Enlargement of cells and increases BP requiring heart to do more work and leads to cardiomegaly
Hypertrophy
Increase in amount of cells and will increase demand
Hyperplasia
Decrease in cell size
Atrophy
Transformation of one cell type to a less specialized type
Metaplasia
What are 3 examples of cellular degenerations
Swelling
Fatty infiltration
Cell necrosis
Water accumulation within the cells
Swelling
Droplets of fat accumulates within cell and liver is often affected due to its role in fat metabolism
Fatty infiltration
Death of cells and enzymes are released that digest dead cells
Cell necrosis
What are 5 examples of liver pathology
Diffuse disease
Parenchyma abnormalities
Focal disease
Masses
Portal hypertension
What are 5 examples of diffuse hepatocellular disease
Fatty infiltration
Glycogen storage disease
Hemochromatosis
Hepatitis
Cirrhosis
Fatty infiltration is what type of disorder
Is an abnormal ? And can interfere with ?
Commonly seen on ?
Non-specific reversible metabolic disorder
Abnormal accumulation of fat within hepatocytes
Commonly seen in U/S
Fatty infiltration can be corrected by
Correction/treatment of primary problem will reverse the process
What are the causes of fatty infiltration
Obesity
Excessive alcohol consumption
Hyperlipidemia
Diabetes
Pregnancy
Chronic hepatitis
Cystic fibrosis
Chemotherapy
Diffuse fatty infiltration increases ?
And if difficult to?
Echogenicity and attenuation of sound beam
Visualize parenchyma, vessels and diaphragm
What does mild diffuse fatty infiltration look like sonographically
Mild increase in echogenicity
What does moderate diffuse fatty infiltration look like sonographically
Difficulty visualizing parenchyma and diaphragm
What does severe diffuse fatty infiltration look like sonographically
Marked increase in echoes, non-visualization of vessels diaphragm
In focal fatty infiltration there is an increase in
Usually occurs near
Might mimic
Can show rapid
Increase in focal area echogenicity
Near porta hepatis
Mimic neoplasm
Rapid change with time
The focal area in focal fatty sparing the liver
How does it appear sonographically
Commonly occurs in ___ near ___
Does not demonstrate fatty infiltration
Hypoechoic area within echogenic liver
Occurs in caudate lobe near porta hepatis
How can you differentiate focal fatty sparing and focal fatty infiltration
Look for mass effect
Normal TSC scan
Areas of low attenuation on CT scan
What is glycogen storage disease
Congenital enzyme deficiency affecting glycogen metabolism
Glycogen storage disease has large amount of ?
Has stunted ?
___ may lead to convulsions
__% mortality
Large amount of glycogen deposited in hepatocytes and kidneys
Stunted growth and platelet dysfunction
Hypoglycemia may lead to convulsions
50% mortaility
GSD usually appears silimar to ?
How does it appear similar
Similar to diffuse fatty infiltration
By:
- Hepatomegaly
- Enalrged kidneys
GSD may also present what type of masses
How do they appear sonographically
Focal solid masses (Adenomas)
Round, echogenic, homogenous
Wha is hemochromatosis
Who is more at risk
What are these patients at higher risk for
Excessive accumulation of iron within the liver
Males more at risk (7:1)
Increased risk for HCC
T or F
Hemochromatosis is not a hereditary disease
False
Is a hereditary disease
How will hemochromatosis be seen on ultrasound
Diffuse increased echogenicity
Attenuation with hepatomegaly
Indistinguishable from fatty infiltration
What is the treatment for hemochromatosis
Weekly removal of the blood
For hemochromatosis with screening and early detection patients will
Have a normal life expectancy
What is hepatitis
What is it caused by
What can this lead to
Inflammation of hepatocytes
Caused by various viruses, drugs, chemicals, and alcohol
Lead to liver failure and death
What are the symptoms of hepatitis
Some will not exhibit clinical symptoms
Loss of appetite
Malaise
Jaundice
Abnormal LFT’s
What are the types of hepatits
Drug induced
A, B, C, D, E
Acute
Chronic
How is Hep A transmitted
What is the recovery rate
Transmitted via fecal-oral route
99% recovery with antibodies
You can have hepatitis but still have a normal
Normal liver scan
Which types of hepatitis are transmitted via blood/body fluis
Hep B, C, and D
For Hep B, C, and D you can be a ?
Can progress to ?
Patients with these have increases risk of?
Can be a carrier and transmit to others
Can progress to chronic liver failure
Increased risk of HCC
You must have Hep ___ to get Hep B
Must get Hep D to get Hep B
Hep E is similar to ?
Common in ?
Transmitted via
Similar to Hep A
Common in India, Asia, and Africa
Transmitted via blood/body fluids
What is a characteristic of drug induced hepatitis
Clinically and histologically indistigushable from viral hepatitis
What are the clinically manifestations of hepatitis
Uncomplicated acute hepatitis
Fulminant
Uncomplicated acute hepatitis have full ___ and usually result from
Full recovery
Result of Hep A
What falls under the fulminant clinical manifestation for hepatitis
Hepatic failure (Possible death)
Jaundice
Coagulopathy
Hepatic encephalopathy
Chronic hepatitis
Most cases of hepatitis
Drug induced toxicity or Hep B
What is chronic hepatitis
Persistence of hepatitis for longer than 6 months
What is the treatment for hepatitis
Prognosis, treatment of chronic hepatits depends on the etiology
What is the sonographic acute hepatitis
Decreased echogenicity
Increased brightness of portal triad walls (Starry sky appearance)
Hepatomegaly
GB wall thickening
What is the sonographic appearance of chronic hepatitis
Hepatic parenchyma progressively damaged
Visualized as course texture, hetergenous, decreased size
Irreversible liver damage that replaces normal liver architecture with abnormal fibrosis nodules
Cirrhosis
With cirrhosis as hepatocytes attemot to regenerate ?
Leads to ?
Replacement of ?
They surround with fibrosis
Leads to scarring of liver tissue
Replacement with fibrotic nodules
What are the classifications of of cirrhosis by size of nodules
What are the most common causes of these classifications
Micronodular <3 mm
- Alcoholism
Marconodular >3 mm
- Chronic viral hepatitis
What are the causes of cirrhosis
What percentage are these causes?
Alcoholic liver disease - 70%
Viral hepatitis - 10%
Biliary causes - 10%
Hemochromatosis - 5%
Other - 5%
What are the 3 types of alcoholic liver disease
Fatty infiltration
Alcoholic hepatits
Alcoholic cirrhosis
T or F:
Fatty lnfiltration is irreversible
False
Is reversible
Alcoholic hepatits may resolve or progress ?
May not have ?
Chronic liver disease
May not have any clinical symptoms
What is associated with alcoholic cirrhosis
Portal hypertension
Ascites
Jaundice
What are the clinical symptoms of alcoholic liver disease
Anorexia
Indigestion
Nausea/vomiting
Diarrhea/constipation
Abdominal pain
Abnormal bleeding
Edema/ascites
Jaundice
Fatigue
Hepatic encephalopathy
When you have abnormal LFT’s you could have an increase in?
Decrease in?
I - PT time, AST/ALT, Bilirubin
D - Total protein, albumin
What is primary biliary cirrhosis?
Destructs?
Causes what to the portal vein?
Leads to ?
Chronic, progressive often fatal form of cirrhosis
Destructs intrahepatic bile ducts
Causes wall inflammation and scarring
Leads to liver failure and itchy skin
What is secondary biliary cirrhosis
Periportal secondary to prolonged obstruction of an extrahepatic biliary tree
What are the sonographic findings of cirrhosis
Volume redistribution - Liver becomes small, shrunken with enlargement of the CL (CL/RL Ratio = 0.65)
Course texture - Increased echogenicity, inhomogeneity
What are the sonographic patterns of cirrhosis
Nodular surface with easily visible with surrounding ascites
Regeneration nodules may mimic neoplasm
What are the associated sonographic findings of secondary biliary cirrhosis
Ascites
Pancreatitis
Narrowed HV’s, and/or IVC by nodular regeneration
Portal hypertension recanalized in the umbilical vein
Cirrhosis
T or F
Ligamentum teres should not have blood in it
True
Bile pigment formed from the hemoglobin portion of destroyed RBC’s
Bilirubin
Where does bilirubin happen in the body
Liver
Spleen
Bone marrows
Unconjugated/indirect bilirubin
Inital non-water soluble that must be carried through blood by albumin
Bilirubin is carried to the ___ and taken up by the ____
Carried by the liver and taken up by hepatocytes
Liver converts indirect bilirubin into
Direct/conjugated bilirubin
Hepatocytes secrete direct bilirubin into the ?
Secrete direct bilirubin into the bile canaliculi in the lobules
Jaundice has elevated levels of
bilirubin in the blood and tissues
What are the 2 types of jaundice
Medical/Non-obstructive and surgical/onstructinve jaundice
What are the characterisitcs associated with hemolytic jaundice
Abnormally large RBC’s being destoryed
Elevated indirect bilirubin
Hepatocytes can’t handle quantity
What is hepatocelluar jaundice
What is elevated
Due to hepatocyte inflammation or fibrosis bile cannot properly be excreted into bile canaliculi
Direct bilirubin is elevated
What is surgical jaundice
What can cause it
What is elevated
Obstruction of bile outflow
Causes:
- Stone in CBD
- Mass in CBD, head of pancreas or duodenum
- Inflammatory stricture
Direct bilirubin is elevated
What are the parenchyma abnormalities
Proximal biliary obstruction
Distal biliary obstruction
Extrahepatic mass
Common duct stricture
Passive hepatic congestion
In the proximal biliary obstruction where is the obstruction located
Proximal to the cystic duct
What are the symptoms of proximal biliary obstruction
Jaundice
Pruritis
Elevated bilirubin and alk phos