Liver Metabolic Disease

Question 1

What factors can cause metabolic disorders of the liver?

Answer 1

Congenital enzyme deficiencies
Nutritional deficiencies
Toxic or chemical damage to organelles
Hypoxic insult
Secondary causes

Question 2

What metabolic issues can be caused by mitochondrial damage in hepatocytes?

Answer 2

Inhibition of beta oxidation of fatty acids leading to microvesicular steatosis
Interference with oxidative phosphorylation leading to insufficient ATP generation
Impairment of the respiratory chain
Apoptosis

Question 3

What drugs are particularly damaging to the mitochondria of hepatocytes?

Answer 3

Antivirals
Salicylate
Valproate
Tetracycline

Question 4

What toxins are particularly damaging to the mitochondria of the hepatocytes?

Answer 4

Hypoglycin

Atractylside

Question 5

Which substance can be particularly depleted by hypoxic ischaemia of the hepatocytes or paracetamol intake?

Answer 5

Glutathione

Question 6

What factors can result in centrilobular necrosis?

Answer 6

Sepsis
Shock induced ischaemia
Congestive heart failure
Toxicity from drugs and poisons

Question 7

The increased storage of lipids, glycogen or other products due to metabolic disease can manifest as….?

Answer 7

Heptomegaly

Question 8

What are the common symptoms of liver metabolic disease?

Answer 8

Vomiting
Failure to thrive
Recurrent episodes of vomiting and encephalopathy with acidosis
Seizures
Heptomegaly possibly with accompanying jaundice