Alcoholic Liver Disease Flashcards
There is a safe lower limit for alcohol ingestion. T/F?
False
Liver damage is related to the amount and duration of alcohol intake. T/F?
True
How does alcohol lead to fatty acid formation in the liver?
Ethanol is oxidised to produced acetylaldehyde which is converted to acetate then acetyl coA which enters the TCA cycle leading to fatty acid formation
What is the main mechanism for the metabolism of alcohol in the liver?
Cytoplasmic alcohol dehydrogenase
What is the inducible mechanism for the metabolism of alcohol in the liver?
Microsomal ethanol oxidising system
The induction of microsomal ethanol oxidising system affects the metabolism of drugs such as paracetamol. T/F?
True
Other than alcohol, what factors can cause fatty liver disease?
Obesity
T2DM
Nutritional imbalances
Drugs such as methotrextate and steroids
Lipid droplets in hepatocytes are seen after how many days of alcohol excess?
2 days
The formation of lipid droplets in hepatocytes due to alcohol excess is reversible. T/F?
True - with abstinence
Alcohol steatosis is usually asymptomatic. T/F?
True
How does alcohol intake increase hepatic lipid?
Altering hepatocyte fat metabolism to promote lipid synthesis
Increasing peripheral fat mobilisation
Reducing lipoprotein synthesis
After how many years of alcohol abuse dose alcoholic hepatitis develop?
3-5 years
Alcoholic hepatitis is more common in men. T/F?
False - it is more common in women
What changes will be seen histologically in the liver with alcoholic hepatitis?
Steatosis
Ballooning of the hepatocytes
Formation of Mallory bodies in the cytoplasm
Necrosis
