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LIVER FUNCTION TEST Flashcards

1
Q

Liver specific enzymes

A

ALT
ALP
5’-NT
GGT

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2
Q

Test method for bilirubin which uses 50% methanol as an accelerator

A

Malloy & Evelyn

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3
Q

In ehrlich’s reaction, diazo salt is composed of:

A

Sulfanilic acid in hydrochloric acid & sodium nitrite

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4
Q

What is the accelerator in Jendrassik & Grof method?

A

Caffeine benzoate-acetate

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5
Q

Conjugated bilirubin which is covalently bound to albumin

A

Delta bilirubin

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6
Q

T or F:

Diazo salt + bilirubin = Azobilirubin

A

True

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7
Q

Final color in Jendrassik-Grof method

A

Blue color

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8
Q

Reference method for total bilirubin

A

Modified jendrassik-grof

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9
Q

What is the conversion factor for bilirubin?

A

17.1

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10
Q

T or F:

Bilirubin is high in adults compared to infants

A

False; higher in infants

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11
Q

Colorless end product of bilirubin metabolism

A

Urobilinogen

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12
Q

Urobilinogen is increased in ___

A

Biliary obstruction
Hepatocellular
Carcinoma (HCC)

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13
Q

Method for urine urobilinogen

A

Modified ehrlich method

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14
Q

Ehrlich’s reagent is composed of ___

A

P-dimethyl aminobenzaldehyde

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15
Q

What does a clay-colored fecal sample indicate?

A

Decreased levels of urobillinogen

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16
Q

Reducing agent in fecal urobilinogen? in urine urobilinogen?

A

Urine - Ascorbic acid

Fecal - Alkaline ferrous hydroxide

17
Q

Why is urine urobilinogen high in pre-hepatic?

A

Due to overproduction of bilirubin; madami nacoconvert to urobilinogen

18
Q

Other name for AST

A

Serum glutamic oxaloacetic transaminase

19
Q

How can you determine if the ALP elevations is due to the liver and not from any other condition?

A

Order 5’-NT test

If normal, it means bone disease. if both ALP and 5’NT is increased, it is a liver disease.

20
Q

A sensitive test for liver disease which can also differentiate biliary obstruction and bone disease

A

y - Glutamyltransferase

21
Q

Disorders in which liver phosphatases are elevated

A

A - lcoholism
B - iliary obstruction
C - irrhosis

22
Q

LDH isoenzyme found in skeletal muscle

A

5-MMMM

23
Q

The only LDH isoenzyme that is important in liver diseases

A

LDH-4

24
Q

2 purposes of PT

A

Test for liver synthetic ability

Biliary obstruction

25
Q

Bile is essential for the absorption of Vitamin K, which is important for what clotting factors?

A

Clotting factors: II, VII, IX, X

26
Q

Also called microdiffusion method and the reference method

A

Conway method

27
Q

Uses bromophenol blue

A

Colorimetric method

28
Q

Only marker that can be detected through liver biopsy

A

HBcAg (Hepa B Core Antigen)

29
Q

Marker for non-infectious state of disease

A

Anti-HBeAg

30
Q

Marker for recovery

A

Anti-HBs

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