Liver Function Flashcards
Hepatic artery provides __% of the total blood supply to the liver while portal vein provides __%.
25%, 75%
Liver cells that line the sinusoids which are capable of engulfing bacteria, debris, and toxins
Kupffer cells
Type of jaundice that yields a gray-colored stool and increased conjugated bilirubin
Post-hepatic jaundice
Inherited disturbance of bilirubin metabolism caused by a genetic deficiency of UDPGT
Criggler Najjar Syndrome
Intermittent unconjugated hyperbilirubinemia in the absence of hemolysis and underlying liver disease due to a defective conjugation system
Gilbert’s Syndrome
Deficiency of canalicular multidrug resistance/multispecific organic anionic transporter protein (MDR2/cMOAT); obstructive hyperbilirubinemia
Dubin-Johnson Syndrome
Conjugated hyperbilirubinemia due to a defective excretion; idiopathic
Rotor’s Syndrome
Enzymes involved in the elimination of alcohol by the liver
Alcohol dehydrogenase and acetaldehyde
Total protein and A/G ratio are tests done to check what function of the liver?
Synthetic
What test determines the liver’s detoxifying function?
Quick’s or Hippuric Acid Test
Which fraction of bilirubin is increased in physiologic jaundice of the newborn?
Unconjugated
Physiologic jaundice among infants is caused by deficiency of which enzymes?
Glucoronyl transferase and UDPGT
___% of the daily production of cholesterol is produced by the liver.
70
Jaundice becomes noticeable to the eye once bilirubin levels reach ___mg/dL.
> 3.0
Defined as the deposition of bilirubin in the brain; common among infants with Crigler-Najjjar syndrome
Kernicterus
The danger of kernicterus is a certainty at levels exceeding ___mg/dL.
20
Dubin-Johnson is caused by a deficiency of the ____ protein.
Canalicular transporter protein (MDR2/cMOAT)
What is the most common malignant tumor of the liver?
Hepatocellular carcinoma
In Reye’s syndrome there is mild ____bilirubinemia & threefold changes in ____ & ____.
Hyper; ammonia; aminotransferases
What is the most important drug which can cause liver damage?
Ethanol
Unconjugated bilirubin is ____ attached to bilirubin.
Noncovalently
What is the bilirubin fraction that is covalently attached to albumin?
Delta bilirubin
If left unprotected from light, bilirubin values may reduce by ____% per hour.
30-50
What is the composition of Ehrlich’s reagent?
para-dimethylaminobenzaldehyde
This enzyme is not present in bone and can be used to differentiate ALP results; more sensitive to metastatic disease.
5’-nucleotidase
