Liver Cirrhosis Flashcards
Anatomy of the Liver
Right and Left Lobes Supplied by hepatic artery and portal vein Drained by hepatic vein 8 anatomical segments Biliary tree
What is the portal vein formed from?
Splenic vein and SMV joining
Portal vein enters liver and divides into R and L branches
Where is blood drained in the liver?
Portal vein -> Central vein -> Hepatic vein -> IVC
What are the immune liver cells?
Kupffer cells
Between blood vessels and sinusoids with other liver cells
What are stellate cells?
Between blood vessels and sinusoids
mesenchymal derived
form collagen when inflammation and scarring
Get damaged in chronic liver failure = portal HTN
What are the functions of the liver?
Protein synthesis = albumin, clotting factors
Carbohydrate Metabolism
Lipid metabolism
Bile production
Immunological function = reticuloendothelial system -> hence sepsis
Hormone & drug metabolism/excretion
Detoxification
What are the 2 components of bile?
Bile pigment = waste product formed from breakdown of RBCs
Bile salt = key product helping lipid breakdown into smaller products for absorption
Why do you get jaundice?
When there is a block in the flow of bile, bile pigments refluxes in circulation = jaundice
Why do you itching?
Reflux of bile salts if blockage of bile
Mechanism of acute liver failure
Hepatocellular dysfunction
Haemodynamic consequences
Symptoms of Hepatocellular dysfunction
Coagulopathy
Jaundice
Encephalopathy
Increased sepsis risk
Haemodynamic symptoms in acute liver failure
As a result of inflammation -> leaky vessels:
Cerebral oedema
Renal failure
Haemodynamic symptoms in chronic liver failure
Due to liver scarring and portal HTN
- splenomegaly
- varices
- ascites
- hepatic encephalopathy
What is the usual pressure of the portal system?
7-10mmHg
Low pressure
How does portal HTN occur?
When liver is scarred in cirrhosis/chronic liver failure the blood from the portal vein struggles to enter this scarred liver. Therefore BP increases inside portal vein.
What happens when there is portal HTN?
> 12mmHg
Causes a back-pressure
Causes opening of collaterals to allow portal vein to empty into systemic circulation (portal-systemic anastomoses)
Portal-systemic anastomoses portal and systemic vessels
Portal circulation is left gastric vein and systemic is azygos vein
Portal circulation is superior rectal vein and systemic is middle and inferior rectal veins
P = paraumbilical vein and S = superficial epigastric vein
P = splenic vein and S = renal vein
Portal-systemic anastomoses sites and condition
Oesophagus = oesophageal varices Fundus of stomach = fundal varices Rectal = rectal varices Paraumbilical = caput medusae Retroperitoneal = splenorenal shunts Also around site of a stoma - peristomal bleeds
What is the mechanism of hepatic encephalopathy?
Bypasses the liver via splenorenal shunts
- normally converts into urea into liver and excreted in urine
- when cirrhosis bypasses liver goes into systemic circulation to the brain = hepatic encephalopathy
- goes into astrocytes = swelling and reduced function
- increases glutamine accumulation
- confusion to coma
What are the clinical features of portal HTN?
- pancytopenia due to splenomegaly
- varices = oesophageal, gastric, rectal
- ascites
- hepatic encephalopathy
Why do you get pancytopenia?
Backpressure of blood in portal system goes to spleen = splenomegaly
Therefore get splenic sequestration -> pancytopenia
Why do you get ascites?
Portal HTN
Splanchnic vasodilation -> decreased circulatory volume -> RAAS activation -> increased sodium retention and renal vasoconstriction
Also low albumin so lower oncotic pressure
What is the commonest porto-systemic site?
Lower Oesophagus
Types of symptoms of chronic liver disease
Asymptomatic for long phase
Cholestatic
Systemic
Decompensation