Liver Cirrhosis

Question 1

Pathological types of cirrhosis

Answer 1

1)micro nodular less than 3mm caused by alcoholic or biliary diseases
2)macro nodular usually following hepatitis

3)mixed

Question 2

Investigation of cirrhosis
2)indicates severe liver disease
3)poor PROGNOSTIC FACTORR

Answer 2

Liver function. S albumin and PT are the best
indicators of liver function
2)low NA
3)S CREATININE>1.47

Question 3

MANAGMENT OF CIRRHOSIS

Answer 3

1)complicated US every 6 m for HCC
2)at risk (A,B vaccine )
#
3) compensated live normally

Question 4

Dietary and drugs avoidance for cirrhosis

Answer 4

1 salt res
2 aspirin ,NSAID,alchohol

Question 5

Poor prognostic indication

Answer 5

1 persistent jaundice
2 failure of responde
3 Ascitis
4 hge from varices
Small liver
Hypotension

Question 6

Prognostic classifications

Answer 6

1)modified Child-
Pugh scoring
2), MELD scoring(focus on S
bilirubin, creatinine and the INR)
widely used in patients awaiting liver tx

Question 7

PBC Associated extrahepatic autoimmune syndromes

Answer 7

SICA
CREST

Question 8

LIVER biochemistry in PBC

Answer 8

S ALP high and usually the only
abnormality

Question 9

PBC TTT

Answer 9

Ursodeoxycholic acid .
• Fat-soluble vitamins (A, D, K) supp

PRuritus: cholestyramine. Rifampicin and naloxone

•Steroids and immunosuppressors should NOT be used

Question 10

which cell in liver cirrhosis is
responsible for fibrosis:

Answer 10

Stellate cell

Question 11

General manifestations of liver
cirrhosis including

Answer 11

parotid enlargement
hyperkinetic circulation
wasting
increased susceptibility to infection

Question 12

MELD scoring focus on :
a-

Answer 12

bilirubin
b- creatinine
c- INR

Question 13

PBC CLINICAL FEATURES

Answer 13

90% are women (40-59 y).
• Asymptomatic.
• Pruritus early.
• Fatigue.
• Jaundice (mild in early cases).
• Hepatomegaly.
• Pigmented xanthelasmas