Introduction Flashcards
Largest organ of the Body
Liver
Serum albumin half life
.18-20 d
Serum bilirubin range
0.1.1 mg /dl
Pt time
INR
Significance
10-13 sec
0.9 - 1,1
Sensitive indicator of both acute and chronic liver disease duo to its short half life
AST,ALT
AST level for adults is: 8
to 48 IU/L.
A normal ALT level for adults is 7 to 55
IU/L.(more specific)
Raised alp
1)raised in both intra hepatic and extra
hepatic cholestatic disease(In cholestatic jaundice, levels may
be 4–6 times)
2-cirrhosis
3) metastases
raised serum γ-GT
If the ALP is normal, , useful guide to alcohol intake.
fatty liver disease
cholestasis
α-Fetoprotein → normal range
2-increased concentration
0 ng/ml to 40 ng/ml.
2)reappearance in increasing and high concentrations
in adults indicates hepatocellular carcinoma (HCC
in pregnancy in blood and
amniotic fluid suggest fetal neural tube defects.
PBC
autoimmune hepatitis
autoimmune,pancreatitis/cholangitis
Antibodies
.IGM
IGG
IGG, 4
AMA
ANCA
Actin
1)pbc(poor prognosis)
2)autoimmune hepatitis.
3)primary sclerosing cholangitis
Genetic analysis is for?
HFE gene)
α1-antitrypsin deficiency.
Wilson diseases
GOLD STANDARD FOR LIVER FIBROSOSS
BIOBSY
CI of liver biopsy
Uncooperative patient
➢ Prolonged INR (>1.5)
➢ Platelets <60×109/L.
➢ Ascites.
➢ Extra hepatic cholestasis
Most effective imaging modality to detect liver parenchymal calcification
CT
Imaging technique show real time visualization of bl flow
US DOPPLER( direction of portal and hepatic
vein blood flow)
LIVER ENZYME located at bile duct epithelium
ALP
