Liver And Pancreas Flashcards
Other than the skin, what is the largest organ in the body?
The liver
Functions of the liver
Storage of glycogen (and many vitamins and minerals), protein metabolism, detox, and production of albumin, bile, and coagulation factors
Byproduct of protein metabolism
Ammonium
Ammonium is sent to the liver to be metabolized into ____ which is sent to the kidneys for excretion as urine
Urea
A phagocytic cell which forms the lining of the sinusoids of the liver and is involved in the breakdown of red blood cells
Kupffer cell
Functions of albumin
Attracts water, transports drugs, binds with calcium
What are the two primary functions of bile?
- Transports waste out of the body (bilirubin (dead RBCs) and cholesterol) 2. Break down fats during digestion
Purpose of coagulation factors
Formation of blood clots
Extensive scarring of the liver caused by necrotic injury or chronic inflammation over a prolonged period of time
Cirrhosis
End-stage liver disease that is characterized by irreversible destruction and degeneration of liver cells
Cirrhosis
In cirrhosis, normal liver tissue is replaced with _____ tissue that lacks function
Fibrotic
Cirrhosis can lead to
Liver failure (b/c scar tissue slows blood flow through liver)
Cirrhosis causes
Postnectrotic, Laennec’s, Biliary
Postnectrotic cirrhosis is caused by
Viral hepatitis, or some medications or toxins
Laennec’s cirrhosis is most commonly caused by
Chronic alcohol use
Biliary cirrhosis is caused by
Chronic biliary obstruction or autoimmune disease
Gastrointestinal S/S of cirrhosis
N/V, anorexia, ascites, gray/tan stools, melena, hematemesis, bleeding esophageal and gastric varices (medical emergency)
Musculoskeletal S/S of cirrhosis
Muscle wasting from poor nutritional status
Respiratory S/S of cirrhosis
Dyspnea and hyperventilation (b/c of ascites), hepaticus (sweet, musty odor of breath caused by accumulated liver byproducts)
Integumentary S/S of cirrhosis
Jaundice (yellowing of skin around eyes/mouth) and itching (d/t accumulation of salts under skin)
Neurologic S/S of cirrhosis
Hepatic encephalopathy
Early clinical manifestations of cirrhosis
Malaise, RUQ discomfort, GI disturbances (anorexia, indigestion, bowel habit changes)
Late clinical manifestations of cirrhosis
Jaundice, esophageal varices, ascites, hepatomegaly, splenomegaly, edema, changes in mental responsiveness and memory, spider angiomas (face, neck, shoulder), anemia, thrombocytopenia
Blood flows out of the liver through ___ hepatic veins into a big vein called the Inferior Vena Cava
3
Oxygen-rich blood flows into the liver through the
Hepatic artery
Nutrient-rich blood coming from the digestive tract, spleen, and pancreas flows into the liver through the
Portal vein
The liver received its blood supply from the hepatic artery and portal vein resulting in about _____ mL of blood flow through the liver every minute
1500
Bile flows out of the liver through the
Bile duct
High blood pressure in the portal vein resulting from an obstruction before, within, or after the liver
Portal hypertension
Portal hypertension most often results from an obstruction _____ the liver due to __________
Within; cirrhosis
S/S of portal hypertension
Ascites, splenomegaly, collateral vessels
Bloating or swelling due to fluid buildup in the abdomen and legs, and third spacing
Ascites
Portal hypertension is classified as > ___ mm Hg
10
_________ is caused by backup of blood into the spleen
Splenomegaly
Splenomegaly can cause
Thrombocytopenia and platelet destruction
Formation of new blood vessels that connect digestive organs directly to general circulation serving as alternate routes for blood to bypass the liver, reduce blood flow to portal vein, and relieving portal pressure
Collateral vessels
Complications of collateral vessels
Variceal bleeding and hepatic encephalopathy
S/S of hepatic encephalopathy
Confusion, drowsiness, tremor, and coma
A network of dilated veins surrounding the umbilicus caused by increased blood flow in the umbilical and paraumbilical veins and is often accompanied by Cruveilhier-Baumgarten murmur
Caput medusae
Audible venous hum over the umbilical vein
Cruveilhier-Baumgarten murmur
What is the root cause of caput medusae?
Portal hypertension
Paracentesis poses a huge risk for
Hemorrhage
Bile is made in the _____ and stored in the _________
Liver; gallbladder
Bile consists of
Waste products, cholesterol, bile salts
Bilirubin that is bound to a certain protein (albumin) in the blood
Unconjugated/indirect bilirubin
Bilirubin that is changed by the liver into a form that the body can get rid of
Conjugated/direct bilirubin
T or F: the liver makes all the cholesterol you need
True! (The remainder of cholesterol in the body comes from diet such as meat, poultry, and dairy)
Yellow discoloration of the skin and mucous membranes caused by an excess accumulation of bilirubin in the blood
Jaundice
Byproduct of red blood cell breakdown
Bilirubin
Jaundice becomes visible when the bilirubin level is approximately ___ - ___ mg/dL
2-3
What are the three main types of jaundice?
Prehepatic, hepatic, and posthepatic
__________ jaundice occurs when RBC lysis exceeds the liver’s capacity to conjugate bilirubin, resulting in large amounts of bilirubin to accumulate in the blood
Prehepatic (hemolytic)
Causes of Prehepatic jaundice
Transfusion reactions, sickle cell anemia, thalassemia, and autoimmune disease
__________ jaundice results from hepatocyte dysfunction which limits the uptake and conjugation of bilirubin, resulting in a rise in the levels of conjugated and unconjugated bilirubin in the blood.
Hepatic
Causes of hepatic jaundice
Hepatitis, cancer, cirrhosis congenital disorders, and drugs
_________ jaundice occurs when gallstones, inflammation, scar tissue, or tumors block the flow of bile into the intestines, resulting in water-soluble conjugated bilirubin to accumulate in the blood
Posthepatic (obstructive)
What type of bilirubin is water soluble?
Conjugated/direct
What type of bilirubin is lipid soluble?
Unconjugated/indirect
How to calculate total and indirect bilirubin
Total = direct + indirect; Indirect = total - direct
An enzyme found in the liver that helps convert proteins into energy for the liver cells. When the liver is damaged, this enzyme is released into the bloodstream and levels increase
Alanine transaminase (ALT)
ALT range
4-36 units/L
An enzyme found in the liver AND bone important for breaking down proteins
Alkaline phosphatase (ALP)
Elevated ALP may indicate
Liver damage/disease (such as blocked bile duct) or certain bone diseases
ALP range
30-120
An enzyme that helps metabolize amino acids, normally present in the blood at low levels. An increase in this enzyme may indicate liver damage, disease, or muscle damage
Aspartate transaminase (AST)
AST range
0-35 units/L
Bilirubin passes through the liver and is excreted in
Stool
Why is serum bilirubin elevated in liver damage/disease?
Due to the inability of the liver to excrete bile
Serum protein range
6.4-8.3 g/dL
Serum albumin range
3.5-5 g/dL
RBC range for males and females
Males: 4.7-6.1; Females: 4.2-5.4
Hematocrit range
12-16
Hemoglobin range
37-47%
Platelets range
150-400k
PT and INR range
PT: 11-12.5; INR: 0.8-1.1
The time it takes blood to clot is called
Prothrombin time (PT)
Ammonia range
6-47
Labs elevated with liver damage/disease
ALT, ALP, AST, bilirubin, PT/INR (prolonged), ammonia
Labs decreased with liver damage/disease
Protein, albumin, RBCs, H&H, platelets
Inflammation of the liver
Hepatitis
HAV transmission
Fecal-oral route
Symptoms of HAV
Loss of appetite, diarrhea, fever, nausea, malaise, jaundice
HAV recovery time
6 weeks
T or F: HAV does not result in permanent liver damage
True
HBV transmission
Via blood or bodily fluids (tears/saliva)
HCV transmission
Via blood or bodily fluids
HCV symptoms
Asymptomatic, flu-like symptoms
HDV transmission
Via blood or bodily fluids; Can only be infected with HDV if you have HBV already