Cancer Flashcards
Series of cellular genetic abberations that cause abnormal cells to proliferate marked by unchecked growth and invasion of surrounding tissues
Cancer
Cancer has the ability to _________ to secondary sites
Metastasize
Cell division
Mitosis
New or continued cell growth not needed for normal development or replacement of dead or damaged cells
Neoplasia
Term used to describe cancer cells moving from primary tumor by breaking off from original site and establishing remote colonies
Metastasize
Cancer development with changing of a normal cell to a cancer cell
Carcinogenesis
Process through which healthy cells become transformed into cancer cells and cells divide in an uncontrolled manner
Oncogenesis
Substances that change the activity of a cell’s genes so the cell becomes a cancer cell
Carcinogens
_________ classifies the number and structure of tumor chromosomes as normal or abnormal
Ploidy
_________ must invade the body first before cancer develops and can be chemical, biological, or environmental
Carcinogens
Term used to describe cells as having an abnormal structure or number of chromosomes
Aneuploidy
Genetic portion of DNA that regulates normal cell growth and repair; A mutation may allow cells to proliferate beyond normal body needs
Proto-oncogens
Mutated genes of normal proto-oncogenes that can give rise to cancer
Oncogenes
Genetic portion of DNA that stops, inhibits, or suppresses cell division
Tumor suppressor genes
Programmed cell death that can lead to cancer if failed
Apoptosis
___ ______ genes make repairs to the DNA caused by carcinogens, but are not able to repair all the damage
DNA repair
Characteristics of benign tumor cells
- Specific morphology (cells look like the tissue they come from)
- nuclear to cytoplasmic ration (nucleus and rest of cell are consistently the same size)
- Specific differentiated functions (acts like normal cells)
- tight adherence
- no migration
- orderly growth
- euploidy (complete set of 23 chromosomes)
Characteristics of malignant tumor cells
- anaplasia
- large nuclear cytoplasmic ration (nucleus larger than rest of cell)
- specific function lost
- loose adherence
- migration occurs
- contact inhibition does not occur (b/c of loss of cellular regulation)
- rapid or continuous cell division
- abnormal chromosomes (more or less than 23)
- angiogenesis (creation of own blood supply)
Describe the process of Carcinogenesis (how cancer metastasizes)
1) malignant transformation, 2) initiation, 3) promotion, 4) progression I and II 5) metastasis
Process by which carcinogens are introduced resulting in increased growth
Promotion
Any tumor greater than ___ sonometers needs oxygen and blood supply
0.5
Adeno: tissue of origin
Epithelial glands
Adeno: benign tumor
Adenoma
Adeno: malignant tumor
Adenocarcinoma