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Liver And Biliary Tract Flashcards

0
Q

5 patterns of liver injury

A 
Inflammation(w granuloma)
Degeneration (swelling and product accumulation)
Cell death (coagulative necrosis)
Regeneration
Fibrosis
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1
Q

Reside i. Subendothelial space of disse, becomes myofibroblassts in liver injury

A

Hepatics stellatec ells

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2
Q

A peculiar body odor related to. Ercaptan formation, sign of hepatic failure

A

Fetor hepaticus

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3
Q

3 characteristics of liver cirrhosis

A

Fibrosis
Nodules
Disruption

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4
Q

Source of extra collagen in cirrhosis

A

Hepatic stellate cell or ito cell

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5
Q

Hepatic vein outflow obstruction causing post hepatic portal hpn

A

Budd chiari syndrome

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6
Q

Uncfjugated bilirubin in the brain

A

Kernicterus

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7
Q

Hereditary UNCONJUGATED hyperbilirubinemias (UGT1A1 impairments)

A

Crigler najjar 1 total absence
Crigler najjar 2 lesse severe deficiency
Gilbert syndrome reduced activity, no clinical symptoms

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8
Q

Hereditary CONJUGATED hyperbilirubinemia

A

Dubin johnson syndrome - liver is brown

Rotor syndrome - liver is not pigmented

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9
Q

Intermittent attacks of cholestasis but wont progress

A

Benign recurrent intrahepatic cholestasis

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10
Q

Mutation in PFIC-1 (progressive familial intrahepatic choletasis)

A

Byler disease

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11
Q

PFIC with low GGTP

A

Pfic 3

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12
Q

Infectious hepatitis

A

Hepa a

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13
Q

Hepa with enveloped dsDNA

A

hepa b

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14
Q

Hepa with no carrier state

A

Hepa a

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15
Q

Hepa that can go chronic

A

Hepa b c d

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16
Q

Hepa that can go cancerous

A

Hepa b c

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17
Q

Hepa that cant occur without hepa b

A

Hepa d

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18
Q

Hepa with high rate of fulmimant hepatitis in pregnant women

A

Hepa e

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19
Q

Non pathogenic hepa

A

Hepa g

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20
Q

Hepatic insufficiency with hepatic encephalopathy within 2 to 3 weeks after symptom onset

A

Fulminant hepatitis

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21
Q

Common cause of hepatic ABSCESS

A

AMEBA and other parasitic infxns

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22
Q

Microvesicular fatty change

A

Tetracycline

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23
Q

Macrovesicular fatty change

A

Ethanol

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24
Diffuse or massive necrosis
Halothane , amanito phalloides, etc
25
Hepatitis acute and chronic
Methyldopa | Isoniazid
26
Fibrosis cirrhosis
Ethanol
27
Granuloma formation
Sulfonamides
28
Cholestasis with or without liver injury
Anabolic steroids
29
Mallory body formation seen in | Eosinophilic aggreages of intermediate filaments
Alcoholic hepatitis
30
Broad pale scar tissues in cirrhotic liver
Laennec? Cirrhosis
31
Seen in children with non alcoholic fatty liver disease
Acanthosis nigricans
32
Test ot highlight tissue accumulation of hemosiderin
Prussian blue
33
Normal level of iron in liver
Less than 1000 microgram per gram dry weight
34
Hfe gene mutations, c282y substitution
Primary hemochromatosis
35
Iron from utensils
Bantu sidaosis
36
Copper accumulation in eyes
Kayser fleischer rings
37
Atp7b gene dfect
Wilson diseasse
38
Most common genetic liver disease in infants
Alpha 1 antitrypsin deficiency
39
Periodic acid schiff positive (diastase resistant) cutoplasmic globules in hepatocytes
Alpha 1 anti trypsin
40
Intrahepatic biliary disease common in MIDDLE AGED WOMEN, autoimmune in origin, with pdc-e2 antibodies
Primary biliary cirrhosis
41
Common cause of SECONDARY biliary cirrhosis in children.. In adults?
Children - biliary atresia | Adults - stones
42
Beading of barium colon Segmental dilatation of bile ala crohns disease Common in middle aged MEN
Primary sclerosinh cholangitis
43
Bile duct hamartoma
Von meyenberg complexes
44
Gene mutated in polycystic liver disease
Hepatocystin (substrate for protein kinase c)
45
Segmental dilatation of larger ducts of intrahepatic biliary disease,
Caroli disease
46
Caroli syndrome is?
Croli diseasewcith congenital hepatic fibrosis
47
Almost complete absence of intrahepatic bile ducts, with jagged notch signaling pathway mutation
Alagille syndrome
48
Systemic hypoperfusion leads to what pattern of necrosis
Centrilobular
49
Where to see nut meg liver (centrilobular hemorrhagic necrosis)
Hypoperfusion with Chronic passive congestion
50
Hepatic sinusoid dilatation with exposure to anabolic steroids.. Mottled and blotchy liver with blood filled lakes
Peliosis hepatitis
51
Venous outflow obstruction , originally described in jamaican drinkers of bush tea.. Now in bone marrow transplant patients
Veno occlusive disease
52
HELLP syndrome
Hemolysis Elevsted liver enzymed Low platelets In PREECLAMPSIA
53
Preeclampsia becomes eclampsia when?
With hyperreflexia and convulsions
54
Aka hepatocyte microvesicular fstty transformation
Acute fatty liver of prregnancy
55
Focal nodular hyperplasia vs nodular regenerative hyperplasia
Nodular regenerative hyperplasia HAS NO FIBROSIS
56
Form of most liver malignancies
Hepatocellular carcinoma
57
Beta catenin mutations cause this tumor of young childhood
Hepatoblastoma
58
Caused by chlroide, arsenic or thorotrast
Angiosarcoma
59
Folded gallbladder fundus
Phrygian cap
60
Cholesterol vs pigment stones based on calcium content
Cholesterol RADIOLUSCENT | pigment RADIOPAQUE
61
Mucosal outpouchings through the wall, seen in chronic cholecystitis
Rokita sky aschoff sinuses
62
Mural dystrophic calcification in chronic cholecystitis
Porcelain gallbladder
63
Fibrosed nodular gallbladder with marked histiocytic inflammation
Xanthogranulomatous cholecystitis
64
Stones within the biliary tree
Choledocholithiasis
65
Bile duct bacterial infection
Ascending cholangitis
66
Congenital dilatations of thr common bile duct, may coexist with caroli disease
Choledochal cysts
67
Common form of gallbladder cancer
Adenocarcinoma,, can be infiltrating or exoohytic
68
Tumors arising at the confluencd of ghe right and left hepatic bile duct
Klatskin tumors

Patho (6 decks)

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