GI tract Flashcards

0
Q

Cracks sa corner ng mouth because of vit b12 deficiency

A

Cheilosis

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1
Q

Syndrome with upper esophageak webs, IDA, glossitis, cheilosis

A

Plummer vinson syndrome under esophageal webs

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2
Q

Upper esophageal mucosal growths

A

Esophageal WEBS

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3
Q

Lower esophageal mucosal overgrowths

A

Esophageal RINGS

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4
Q

Pharyngo-esophageal diverticulum

A

Zenker diverrticulum, with risk of aspiration

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5
Q

Mid esophageal diverticulum, asymptomatic

A

Teaction diverticulum

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6
Q

Diverticulum above lower esoph sphincter, NOCTURNAL regurg

A

Epiphrenic diverticulum

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7
Q

Failure of cardiac sphincter to relax, increasing risk of esoph squamous cell carcinoma

A

Achalasia

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8
Q

Causes gastric protrusion into the thorax

A

Hiatal hernia

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9
Q

Common cause of esophageal varices

A

Portal HPN from alcoholic liver disease

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10
Q

Complication of long standing GERD, dysplastic cells may lead to ADENOCARCINOMA

A

Barret esophagus

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11
Q

Longitudinal tears in esophagus, due to severe vomiting

A

Mallory weiss syndrome

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12
Q

Pressure rupture of the esophagus, from vomiting due to alcohol

A

Boerhaave syndrome

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13
Q

Most common esophageal cancer

A

Squamous cell carcinoma from smoking and alcohol

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14
Q

Acute gastric ulcers common cause

A

Stress or NSAID use

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15
Q

Curling ulcers vs cushing ukcers

A

Curling - prox duodenum, assoc w burns and trauma

Cushing - in px with intracranial disease

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16
Q

Top 2 most common causes of CHRONIC gastritis

A

1) h pylori infection and 2) autoimmune gastritis

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17
Q

H pylori vs autoimmune gastritis

A

H pylori - antrum, hypogastrinemia, 90% of gastritis cases

Autoimmue - hypergastrinemia, antral G cell hyperplasia

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18
Q

Causes of uncommon forms of gastritis

A

Reactive gastropathy - chemical injury
Eosinophilic gastritis - allergic rxn
Lymphocytic gastritis - idiopathic, women, celiac dse

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19
Q

Sharply punched out defect
overhanging mucosal borders
Smooth clean ulcer bases

A

Peptic ulcer disease

20
Q

DIFFUSE foveolar cell hyperplasia with protein losing enteropathy due to tgf-a overexpression

A

Menetrier disease (hypertrophicg astropathy)

21
Q

Gastrin secreting tumors causes gastric parietal cell stimulation, ukcers and diarrhea

A

Zollinger ellison syndrome

22
Q

Gastric adenoma common location

A

Gastric antrum, with intestinal type columnar epithelium

23
Q

Most common gastric cancer

A

Gastric adenocarcinoma

24
Q

Intestinal morphology vs diffuse infiltrative gastric adenocarcinoma

A

Intestinal - bulky exophytic tumors with glandular structures, arisef rom dysplasia and adenomas
Diffuse infiltrative - signet ring cells, no glands, no precursor lesions

25
Q

Diagnostic for gastric lymphoma

A

Lymphoepithelial lesions - neoplastic lymphocytes infiltrate the gastric glands focally

26
Q

Diffuse components of the endocrine system found inthe GIT, Most common in SI

A

Carcinoid tumor

27
Q

Most common mesenchymal tumor of abdomen

A

GI stromal tumor (GIST)

28
Q

Known mutations causing GIST

A

C kit and PDGFRA

29
Q

Solitary, well circumscribed fleshy masses that can grow as large as 30 cm

A

GIST

30
Q

4 common causes of intestinal obstruction

A

Hernia, adhesions, volvulus, intussusception

31
Q

Intussusception in infants caused by _______ and treated with _______.

A

Rotavirus infection; barium enema

32
Q

Most common presentation of malabsorption syndrome

A

Chronic diarrhea

33
Q

Hallmark of malabsorption syndrome

A

Steatorrhea

34
Q

4 phases of nutrient absorption that can be disrupted in malabsorption syndromes

A

Intraluminal digestion
Terminal digestion
Transepithelial transport
Lymphatic transport

35
Q

Prototype non infectious cause of malabsorption

A

Celiac sprue

36
Q

Diffuse enteritis with marked atrophy of villi, aka gluten sensitive enteropathy

A

Celiac sprue

37
Q

Hallmark of WHIPPLE DISEASE

A

PAS positive macrophages in the lamina propria (intestine, CNS or joints)

38
Q

Causative agent of WHIPPLE DISEASE

A

Tropheryma whippelii, a gram positive and culture rsistant actinomycete

39
Q

Uncommon total villous atrophy, like celiac spruw

A

Tropical sprue

40
Q

Autoantibodies to enterocytes and goblet cells

A

Autoimmune enteropathy

41
Q

Autoimmune enteropathy gene mutation

A

FOXP3 gene

42
Q

Due to MTP mutation (microsomal triglyceride transfer protein)

A

Abetalipoproteinemia

43
Q

Napkin ring configuration of tumor

A

SI adenocarcinoma

44
Q

Give 3 benign tumors of SI

A

Brunners gland adenoma
Adenomas
Hamartomatous polyps

45
Q

Acute enteritis caused by?

A

Infections

46
Q

Two conditions under CHRONIC ENTERITIS

A

Crohns disease

Ulcerative colitis

47
Q

Crohns disease related genes

A

NOD2
ATG16L1
IRGM