Lipoproteins

Question 1

A-I

Answer 1

Activates LCAT

Chylomicrons and HDL

Question 2

C-II

Answer 2

Lipoprotein lipase cofactor

Chylomicrons, VLDL, HDL

Question 3

B-48

Answer 3

Chylomicron secretion

Chylomicron, Chylomicron remnant

Question 4

B-100

Answer 4

Binds LDL receptor

VLDL, IDL, LDL

Question 5

Apo E

Answer 5

Mediates remnant uptake in liver

All except LDL

Question 6

Chylomicrons fxn

Answer 6

Delivers TG to peripheral tissue

Delivers cholesterol to liver (Chylomicron remnants)

Question 7

VLDL fxn

Answer 7

Delivers hepatic TG to peripheral tissue

Question 8

IDL fxn

Answer 8

Delivers TG and cholesterol to liver

Question 9

LDL

Answer 9

Delivers hepatic cholesterol to peripheral tissue

Question 10

HDL fxn

Answer 10

Reverse cholesterol transport from periphery to liver

Repository for Apo E and Apo C

Question 11

Increased chylomicrons, TG, cholesterol

Answer 11

Type 1 - hyperchylomicronemia

Lipoprotein lipase deficiency or altered Apo C-II

Question 12

Increased LDL, cholesterol

Answer 12

Type IIa - familial hypercholesterolemia

Absent or defective LDL receptors

Question 13

Increased VLDL, TG

Triad of CAD, DM type II, obesity

Answer 13

type IV - hypertriglyceridemia

Overproduction of VLDL

Question 14

High VLDL and chylomicrons

Answer 14

Type III - familial dysbetalipoproteinemia

Question 15

No chylomicrons, VLDL or LDL

Intestinal malabsorption

Answer 15

Abetalipoproyeinemia

No Apo B48 and Apo 100