Glycolysis

Question 0

Has high affinity and low Km for glucose

Answer 0

Hexokinase

Question 1

End products of glycolysis

Answer 1

Pryruvate or Lactate

Question 2

Glucokinase vs Hexokinase - which has lower Km?

Answer 2

Hexokinase - picks up glucose faster

Question 3

Glucokinase vs Hexokinase - which has higher Vmax?

Answer 3

Glucokinase

Provides glucose 6-p in excess of requirements for glycolysis

Question 4

Net ATPs from 1 glucose molecule via substrate level phosphorylation

Answer 4

2 ATP molecules

Question 5

Organs that utilize the malate-aspartate shuttle

Answer 5

Liver, kidney, heart

Question 6

Where is the ETC?

Answer 6

Inner mito membrane

Question 7

ATPs from 1 NADH in malate aspartate shuttle?

Answer 7

1 NADH = 3 ATP

Question 8

ATPs from 1 NADH in glycerol phosphate shuttle

Answer 8

1 NADH = 2 ATP

Question 9

Organs that utilize anaerobic glycolysis

Answer 9

RBC
WBC
Lens, cornea 
Kidney medulla
Testes 

• without mitochondria

Question 10

Arsenic poisoning pathophysiology

Milk and roses complexion, Mee’s lines, garlicky odor

Answer 10

Inhibits pyruvate dehydrogenase by binding to lipoic acid

Question 11

Co-enzymes of pyruvate dehydrogenase

Answer 11

B1-TPP
B2-FAD
B3-NAD+
B5-Coenzyme A
Lipoic acid

Question 12

Inheritance of pyruvate dehydrogenase deficiency

Answer 12

X-linked dominant

Like Alport and Vit-D resistant rickets

Question 13

MCC of congenital lactic acidosis

Answer 13

Pyruvate dehydrogenase deficiency

Question 14

Tx for pyruvate dehydrogenase deficiency

Answer 14

Ketogenic diet