Lipogenesis Flashcards
What is the starting input for lipogenesis and what is the final output?
Input: many acetyl CoA
Output: one fatty acid and oxidised NADP+
Once three fatty acids are produced they join to a glycerol to make a TAG, stored as fat in adipose tissue
Where does the input required for lipogenesis come from?
acetyl CoA comes from carb metabolism
glucose - pyruvate (glycolysis)
pyruvate - acetyl CoA (aerobic resp)
Once energy stores are met lipogenesis begins
How is acetyl CoA moved from mitochondria to cytosol?
moved from mitochondria to cytosol via citrate malate shuttle, CoA component is removed than reattached.
How is the acetyl CoA used to begin lipogenesis?
Once in cytosol, acetyl CoA is converted to acetyl ACP and malonyl ACP.
Acetyl ACP and malonyl ACP used to make acetoacetyl ACP in first step of lipogenesis.
What is the final output of lipogenesis?
For what purpose?
three fatty acids made via lipogenesis bond to a glycerol to form triacylglycerol units, which can be stored as fat in adipose tissue
TAGs can be used for energy generation in fasting state
Why is lipogenesis important?
allows carbs to be converted to fatty acids.
fatty acids converted to TAGs and stored.
prevents wastage of carbs and provides source of energy in fasting state
