Lipids Skildum Flashcards
Most calorically dense food?
Fat
What particle functions to promote cholesterol homeostasis?
HDL
They take excess cholesterol from the tissues back to the liver where it can be converted into bile salts etc.
Which lipoprotein activates an extracellular lipase in capillary beds?
ApoCII
*Activates lipoprotein lipase
What can we do with excess de novo glucose in our bodies?
Make Fatty acids!
Main storage form of energy in our body?
Triacylglycerol
Key intermediate between fatty acids and prostaglandins & leukotrienes and thromboxanes?
Arachidonic acid!
How do prostaglandins and thromboxanes play into achalasia?
They can chemically signal a tonically contracted LES
What acts to break up fat down into a lot of little tiny globs of fat?
Bile acid salts
Where are lipases secreted from?
pancreas
At what point does fat composition change after swallowing?
In the small intestine
What hormones promote secretion of bile and lipases into the lumen of the gut?
*Cause contraction
Secretin & Cholecystokinin (CCK)
Why do people with CF often have malabsorption of lipids?
Secretion of lipases is deficient because of pancreatic duct blockage
Where does pancreatic lipase cut on triacylglycerol?
1 and 3 positions
What is the end product of pancreatic lipases function?
2 fatty acids + 2-monoacylglycerol
What do the products of pancreatic lipase combine with once taken up by gut epithelial cells before they become chylomicrons that enter the lymph system and then the blood?
ApoB48
