Esophageal Disorders/GERD - Erickson Flashcards

1
Q

Define odynophagia

A

Pain on swallowing

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2
Q

Define dysphagia

A

Symptom resulting from the failure to move a food bolus from the mouth to the stomach

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3
Q

What are some factors that can contribute to dysphagia?

A
  • reduced saliva/mastication
  • Neuromuscular disorders
  • Impaired mental function
  • Motility disturbances
  • Mechanical obstruction
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4
Q

What are symptoms of dysphagia?

A
  • difficulty swallowing

- food stops/ “sticks” after swallowing is initiated

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5
Q

Difficulty initiating swallowing would indicate what type of dysphagia?

A

Oropharyngeal dysphagia

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6
Q

Food stops/or sticks after swallowing in initiated would indicate what type of dysphagia?

A

Esophageal Dysphagia

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7
Q

What are the 3 goals of treatment for oropharyngeal dysphagia?

A
  1. Protect Airway
  2. Maintain nutrition
  3. Relieve Dysphagia
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8
Q

What is achalasia?

A

Loss of inhibitory innervation to the LES (tonically contracted LES)

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9
Q

In what condition would you see a bird’s beak narrowing at LES, and a dilated esophagus on a barium swallow?

A

Achalasia

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10
Q

What are the 4 treatment options for Achalasia?

A
  • Nifedipine (calcium channel blocker)
  • Botulinum Toxin (blocks ACh release)
  • Balloon Dilation
  • Esophagogastric Myotomy
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11
Q

Esophageal dysphagia intermittent with solids only

A

Lower esophageal ring

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12
Q

Progressive esophageal dysphagia with solids only

A

Peptic Stricture

Cancer

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13
Q

Intermittent esophageal dysphagia with solids and liquids

A

Diffuse spasm
NEMD
Nutcracker

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14
Q

Progressive esophageal dysphagia with solids and liquids

A

Achalasia

Scleroderma

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15
Q

What is the classic symptom of GERD? Other common symptoms?

A

Heartburn = classic
Regurgitation
Belching
Water brash (regurgitation of excess saliva from lower esophagus often with lots of stomach acid)

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16
Q

What are 3 symptoms associated with complications of GERD?

A

Dysphagia
Odynophagia
Bleeding

17
Q

What 2 ways do hiatal hernia contribute to reflux?

A
  1. No diaphragmatic support of LES
  2. HH is reservoir for gastric contents

Note: many hiatal hernias are not associated with reflux

18
Q

What diagnostic studies should you order to diagnose GERD?

A

Trick questions!

Diagnostic studies are NOTneeded with classic history, start empiric treatment

19
Q

What is the best initial diagnostic study for patients with reflux symptoms and dysphagia?

A

Barium Swallow

20
Q

What is the best diagnostic study for evaluating mucosal injury? (like esophagitis, barrett’s epithelium, hiatal hernia, strictures)

21
Q

What is the best study to confirm GERD?

A

Ambulatory pH monitoring

22
Q

What is the cornerstone of GERD therapy?

A

Life-style modifications!!

  • elevate bed
  • no food 3 hours before bed
  • stop smoking
  • modify diet
  • check medications
  • OTC med prn
23
Q

What medications can decrease LES pressure?

A

Theophylline
Anticholinergics
Ca Channel blockers
Nitrates

24
Q

What medications can injure mucosa?

A
Tetracyclines
Quinidine
NSAIDS
K+ tablets
Iron Salts
25
Cimetidine Ranitidine Famotidine Nizatindine Are all examples of what? to treat?
H2 receptor antagonists | GERD therapy
26
Omeprazole Lansoprazole Are examples of what? to treat?
Proton pump inhibitors to treat GERD
27
Define Barrett's Esophagus
Columnar epithelium replaces squamous epithelium in distal esophagus DER injures squamous epithelium and promotes repair by columnar metaplasia
28
What is a major risk factor for esophageal adenocarcinoma?
Barrett's Esophagus!!!!
29
What is the pathogenesis for peptic esophageal strictures?
Ulcerations stimulate fibrosis often associated with NSAIDS
30
What neurotransmitters are missing in Achalasia?
VIP, NO
31
Is the difficulty in swallowing solids and liquids intermittent or progressive in Achalasia?
Progressive
32
Why is botulinum toxin effective in Tx of Achalasia?
Inhibits ACh release...allowing the LES to relax
33
Most common cause of GERD?
Transient LES relaxations
34
Is it hard to swallow solids only or solids & liquids with esophageal cancer or a peptic stricture?
Solids only | Progressive
35
What is water brash?
Saliva over production!
36
Prototype patient for eosinophilic esophagitis?
Young male with history of atopic disease