Lipids

Question 1

Who to screen with lipid panel?

Answer 1

Men >= 40, women >= 50 or postmenopausal (consider earlier in SE Asians, First Nations)

or

smoker, DM, HTN, Fam hx premature CVD/hyperlipidemia, ED, CKD, inflammatory disease, HIV, COPD, atherosclerosis/AAA, BMI > 27

Question 2

How often to repeat lipids?

Answer 2

FRS <5%: Q3-5 years

FRS >= 5%: Q1 year

Question 3

CCS Lipid Guidelines Risk Stratification (LR, IR, HR)

Answer 3

Question 4

CCS Lipid IR Stratification

Answer 4

Question 5

CCS Lipid Guidelines Treatment Targets + Thresholds

Answer 5

Question 6

Other lipid-lowering drugs

Answer 6

• ezetemibe: inhibits cholesterol absorption, may add on to statin, check LFT’s more freq
• fibrates: fenofibrate (Lipidil), best to lower TG. May add on to statin but watch for myopathies
• niacin: raises HDL
• cholesterol binders & resins: cholestyramine, may add on to statin. Do not use if high TG