Lipids Flashcards
What is the best medication CLASS* for hypercholesteremia?
Statins
What 2 things do statins do to decrease cholesterol?
Inhibit HMG-CoA within the liver to block cholesterol making
Increases LDL receptors to receive cholesterol from blood
What do the names of statin end with?
Statin
What are two medications that are adjuncts for statins in order to work well?
Bile acid binding resins
Cholesterol absorption inhibitors
What medications can increase the ADR of a statin?
Niacin and fibrates
What two medications are used for hypertriglycerides?
Niacin and Fibrates
What is a ADR for resins?
They decrease vitamin absorption.
What medication is probably contraindicated for diabetes?
Niacin, they increase glucose.
What are major ADRs of statins
Myalgia
Rhadomyolysis
Hepatoxicity (increased liver enzymes)
Teratogen
What is the best way to lower LDL
Statin + Cholesterol Absorbing Inhibitor
Statin + Ezetimibe
What are PCSK9 inhibitors?
They inhibit the enzyme that degrades LDL receptors.
What are the names of the PCSK9 inhibitors
evolocumab
alirocumab
what is INclisiran?
small interfering RNA (siRNA) that inhibits translation of PCSK9
What is the ACL inhibitor?
Bempedoic acid. It limits ATP citrate lyase.
What is the ACL inhibitor used for?
Used when statin therapy is maxed out for the treatment of heterozygous familial hypercholesterolemia or atherosclerotic CVD
