Lipid Transport Flashcards by Ryan Bray | Brainscape

Q

A-I?

A

Activates LCAT

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Q

B-100?

A

Binds to LDL receptor, mediates VLDL secretion

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Q

C-II?

A

Cofactor for LPL

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Q

B-48?

A

Mediates chylomicron secretion

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Q

E?

A

Mediates Extra (remnant) uptake

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Q

Pancreatic lipase?

A

Degrades dietary TGs in SI

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Q

LPL?

A

Degrades TGs circulating in chylomicrons and VLDL

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Q

Hepatic TG lipase?

A

Degrades TGs remaining in IDL

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Q

Hormone sensitive lipase?

A

Degrades TGs stored in adipocytes

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Q

LCAT?

A

Catalyzes esterification of cholesterol

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Q

CETP?

A

Mediates transfer of cholesterol esters to other lipoprotein particles

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Q

Acts as repository for apoC and apoE?

A

HDL

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Q

Defect in type I?

A

LPL or C-II

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Q

Defect in type IIa?

A

LDL receptor

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Q

Defect in type IIb?

A

apo100

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Q

Defect in type III?

A

ApoE3 and E4

Q

Defect in type IV?

A

Hepatic overproduction of VLDL

Q

What is increased in type I?

A

Chylomicrons, TGs, cholesterol

Q

What is increased in types IIa and b?

A

LDL and cholesterol

Q

What is increased in type III?

A

Cholesterol and remnants

Q

What is increased in type IV?

A

VLDL and TGs

Q

Which one has NO risk for atherosclerosis?

A

Type I

Q

Which presents with pancreatitis?

A

Types I and IV

Q

Familial hyperchylomicronemia?

A

Type I

Q

Familial dysbetalipoproteinemia?

A

Type III

Q

Familial hypercholesterolemia?

A

Type II

Q

Hypertriglyceridemia?

A

Type IV

Q

Deficiencies in B100 and B48?

A

Abeta-lipoproteinemia–decreased chylomicron and VLDL synthesis and secretion