Lipid Storage Flashcards
How are fats stored in the body?
Triacylgylcerols (TAG)
Hydrophobic and are therefore stored in an anhydrous form in adipose tissues
Why is it difficult to keep weight off after being fat?
Because you have increased your number of adipocytes and they want to be filled with fat.
Adipocytes can increase in size and will eventually divide and increase in number
What is the process of fatty acid synthesis?
Lipogenesis
What is the key regulating hormone in liver lipogenesis?
Acetyl-CoA carboxylase
What effects do insulin and citrate have on acetyl CoA carboxylase activity?
They increase it
What effect does glucagon/adrenaline and AMP have on acetyl-coa decarboxylase?
They decrease the activity
What is the process of fat mobilisation?
Lipolysis
What hormone catalyses lipolysis?
Hormone sensitive lipase
What effect does glucagon and adrenaline have on hormone sensitive lipase?
Lead to phosphorylation and activation of it because you want to gain energy
It causes lipolysis to occur
What effect does insulin have on hormone sensitive lipase?
It leads to de-phosphorylation and inhibition of it
Causes lipolysis to stop
