Lipid Catabolism

Question 0

Breakdown fatty acids process

Answer 0

Beta-oxidation

Question 1

Energy storage locations

Answer 1

Adipose
Protein
Glycogen (muscle)
Glycogen (liver)
Glucose

Question 2

Beta-oxidation location

Answer 2

Mitochondria in eukaryotes

Question 3

Enzymes for fatty acid into mitochondria

Answer 3

Carnitine transferase 1, translocase, carnitine transferase 2

Question 4

Short fatty acids into mitochondria

Answer 4

Imported then attached to CoA

Question 5

Long fatty acids into mitochondria

Answer 5

Use carnitine system

Activated outside, transported, reactivated

Question 6

ETF

Answer 6

Electron transfer flavoprotein: accepts electrons from other flavoproteins
Electrons from the reduced flavin pass into the ETC

Question 7

Enegetics of beta-oxidation

Answer 7

Adds FADH2 and NADH to TCA cycle

100 ATP yield

Question 8

Ketone bodies

Answer 8

Produced in liver (matrix mitochondria)

Rapidly mobilized fuel sources

Question 9

Ketogenesis

Answer 9

Forms ketone bodies

by products: acetone, acetoacetate, beta-hydroxybutyrate

Question 10

Steps ketogenesis

Answer 10

1: condensation of acetyl-CoA form acetoacetyl-CoA catalyzed by thiolase
2: add additional molecule of acetyl-CoA to produce HMG-CoA
3: HMG-CoA converted to acetoacetate by HMG-CoA lyase
4: acetoacetate further reduced by action of beta- hydroxy butyrate dehydrogenase

Question 11

Enzymes of ketogenesis

Answer 11

Thiolase, HMG-CoA lyase, beta-hydroxy butyrate dehydrogenase

Question 12

Odd number of carbons product

Answer 12

Succinyl-CoA

Question 13

Enzymes beta-oxidation

Answer 13

Acyl- CoA dehydrogenase, enoyl-CoA hydrase, L-hydroxyacyl-CoA dehydrogenase, thiolase