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Hematology Lecture > Lineage Specific Hematopoesis > Flashcards

Lineage Specific Hematopoesis Flashcards

1
Q

During the maturation of a normal red blood cell, there will be normal changes that will happen or occur in terms of the:

A

Size
Nucleus
Cytoplasm
Chromatin
Granules

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2
Q

Fill in the blanks:

The cytoplasm of an immature cell is usually _____ or _____ due to RNA content.

A

Blue
Basophilic

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3
Q

True or False

The more mature the cell, the more basophilic because of the less RNA.

A

False

The more mature the cell, the less basophilic because of the less RNA.

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4
Q

Fill in the blank:

In _____, the cytoplasm contains granules.

A

Myeloid

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5
Q

The _____ is also known as acidophilic or eosinophilic granules.

A

Red (Acidic) Dye

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6
Q

The _____ is also known as the basophilic granules.

A

Blue (Basic) Dye

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7
Q

Combined basic and acidic dye.

A

Neutrophilic Granules

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8
Q

Special feature of the maturation of erythrocytes cells.

A

Elaboration of Hemoglobin

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9
Q

There are how many Series of Maturation?

A

6 Series of Maturation

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10
Q

Fill in the blanks:

At the mature stage of the hemoglobin, the nucleus is apparently no longer necessary and eliminated by _____ or _____.

A

Nucleolysis
Extursion

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11
Q

Fill in the blank:

A good example of nucleolysis is _____.

A

Erythrocytes

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12
Q

Fill in the blank:

In the nuclear changes, the immature nucleus is round or oval and the nuclear chromatin is very delicate, fine, and linear and is called _____.

A

Euchromatin

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13
Q

Give the characteristics of Euchromatin:

A

Very delicate
Fine
Linear
Pale Blue
Uncondensed

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14
Q

Fill in the blank:

As the cells matures, chromatin stands increasingly coarse and clumped _____.

A

Heterochromatin

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15
Q

RBC Inclusion Bodies:

A

Pappenheimer
Howell Jolly Bodies
Heinz Bodies

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16
Q

WBC Inclusion Bodies:

A

Alder-Reilly

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17
Q

If the nucleus is hyposegmented, what condition is associated?

A

Pelger Huet Anomaly (Lack of Lamin B)

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18
Q

In the erythrocyte series, what is larger in terms of size?

A

Megaloblasts are larger than normal mature erythrocytes

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19
Q

3 Stem Cells:

A

Totipotent Stem Cells
Pluripotent Stem Cells
Multipotent Stem Cells

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20
Q

First recognizable cell in the series of granular poesis is the _____.

A

Myeloblasts

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21
Q

2 progenitors in the Human Hematopoesis:

A

Common Myeloid Progenitors
Common Lymphoid Progenitors

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22
Q

First recognizable erythroid precursor.

A

Pronormoblast (Rubriblast)

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23
Q

Basophilic Normoblast (Prorubricyte) is mistaken as Pronormoblast (Rubriblast). To differentiate, what are the criteria in distinguishing which of which?

A
  1. Prorubricyte has coarse chromatins
  2. Absence of nucleoli
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24
Q

First stage of Hemoglobin synthesis in Erythropoiesis.

A

Basophilic Normoblast (Prorubricyte)

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25
Q

Polychromatic (Polychromatophilic) Normoblast
(Rubricyte) can be mistaken as Lymphocytes. To differentiate, what are the criteria?

A
  1. Lymphocytes have crushed velvet nucleus and cytoplasm is sky blue
  2. In Rubricyte, nucleus is checker board and cytoplasm is muddy or gray
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26
Q

It is the last stage in the Erythropoiesis where the mitosis stops.

A

Polychromatic (Polychromatophilic) Normoblast
(Rubricyte)

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27
Q

Orthochromic Normoblast (Metarubricyte) is also known as _____

A

Late Normoblast

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28
Q

Last stage to synthesize Hemoglobin in Erythropoiesis.

A

Reticulocyte

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29
Q

Last stage in bone marrow before release to the blood in Erythropoiesis.

A

Reticulocyte

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30
Q

Best indicators of bone marrow functions.

A

Reticulocyte Count

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31
Q

This stain is used to visualize Reticulocytes.

A

Supravital Stain

32
Q

Reference Range of Reticulocyte in Adults.

A

0.5% to 1.5%

33
Q

Reference Range of Reticulocyte in Newborn.

A

2% to 6%

34
Q

Last stage in the Erythropoiesis.

A

Erythrocyte

35
Q

If an Erythrocyte has no central pallor, it indicates what issue?

A

Spherocytes

36
Q

Enumerate the Normoblastic Nomenclature for Erythroid Precursors:

A

Pronormoblast
Basophilic Normoblast
Polychromatic Normoblast
Orthochromatic Normoblast
Reticulocyte
Erythrocyte

37
Q

Enumerate the Rubriblastic Nomenclature for Erythroid Precursors:

A

Rubriblast
Prorubricyte
Rubricyte
Metarubricyte
Reticulocyte
Erythrocyte

38
Q

Enumerate the Erythroblastic Nomenclature for Erythroid Precursors:

A

Proerythroblast
Basophilic Erythroblast
Polychromic Erythroblast
Orthochromic Erythroblast
Reticulocyte
Erythrocyte

39
Q

Identify:

Pronormoblast Size

A

12-20 um

40
Q

Identify:

Pronormoblast Nucleus to Cytoplasm Ratio

A

8:1

41
Q

Identify:

Pronormoblast Nucleoli

A

1-2

42
Q

Identify:

Pronormoblast Percentage in Bone Marrow

A

1%

43
Q

Identify:

Pronormoblast Transit Time in Bone Marrow

A

24

44
Q

Identify:

Pronormoblast Division

A

Mitosis (2)

45
Q

Identify:

Basophilic Normoblast Size

A

10-15um

46
Q

Identify:

Basophilic Normoblast Nucleus to Cytoplasm Ratio

A

6:1

47
Q

Identify:

Basophilic Normoblast Nucleoli

A

0-1

48
Q

Identify:

Basophilic Normoblast Percentage in Bone Marrow

A

1-4%

49
Q

Identify:

Basophilic Normoblast Transit Time in Bone Marrow

A

24

50
Q

Identify:

Basophilic Normoblast Division

A

Mitosis (4)

51
Q

Identify:

Polychromic Normoblast Size

A

10-12 um

52
Q

Identify:

Polychromic Normoblast Nucleus to Cytoplasm Ratio

A

4:1

53
Q

Identify:

Polychromic Normoblast Nucleoli

A

0

54
Q

Identify:

Polychromic Normoblast Percentage in Bone Marrow

A

10-20%

55
Q

Identify:

Polychromic Normoblast Transit Time in Bone Marrow

A

24

56
Q

Identify:

Polychromic Normoblast Division

A

Mitosis (16)

57
Q

Identify:

Orthochromic Normoblast Size

A

8-10 um

58
Q

Identify:

Orthochromic Normoblast Nucleus to Cytoplasm Ratio

A

1:2

59
Q

Identify:

Orthochromic Normoblast Nucleoli

A

0

60
Q

Identify:

Orthochromic Normoblast Percentage in Bone Marrow

A

5-10%

61
Q

Identify:

Orthochromic Normoblast Transit Time in Bone Marrow

A

48

62
Q

Identify:

Orthochromic Normoblast Division

A

Not applicable

63
Q

Identify:

Reticulocyte Size

A

8-10 um

64
Q

Identify:

Reticulocyte Nucleus to Cytoplasm Ratio

A

Not applicable

65
Q

Identify:

Reticulocyte Nucleoli

A

0

66
Q

Identify:

Reticulocyte Percentage in Bone Marrow

A

1%

67
Q

Identify:

Reticulocyte Transit Time in Bone Marrow and in Peripheral Blood

A

Bone Marrow = 1-2 days
Peripheral Blood = 1 day

68
Q

Identify:

Red Blood Cell Size

A

Diameter = 6-8 um
Thickness = 1.5-2.5 um

69
Q

Identify:

Red Blood Cell Nucleus to Cytoplasm Ratio

A

Not applicable

70
Q

Identify:

Red Blood Cell Nucleoli

A

0

71
Q

Identify:

Red Blood Cell Percentage in Bone Marrow

A

0

72
Q

Identify:

Red Blood Cell Transit Time in Bone Marrow and in Peripheral Blood

A

Bone Marrow = 0
Peripheral Blood = 120 days

73
Q

Identify:

Red Blood Cell Division

A

Not applicable

74
Q

Enumerate the Granulopoiesis in chronological order:

A

Myeloblast
Promyelocyte
Myelocyte
Metamyelocyte
Non-segmented Granulocyte
Segmented Granulocyte

75
Q

The first or earliest recognizable granulocyte precursor

A

Myeloblasts

76
Q

3 Types of Myeloblasts:

A

Type I - Nucleus is open
Type II - Presence of primary granules
Type III - Darker in color

Hematology Lecture (6 decks)

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