Lincosamides

Question 1

Clindamycin

Answer 1

Bacterial static or cidal depending on concentration and susceptibility; when bacteriocidal concentrations are reached, clindamycin exhibits time-dependent killing
Effective against many anaerobes, gram positive aerobic cocci, toxoplasma; excellent activity against staphylococci and streptococci; ineffective against gram negative bacteria

Binds to 50S ribosomal subunit, inhibiting peptide bond formation and protein synthesis of the bacterial cell wall

has activity against a variety of protozoal organisms, but not effective against tachyzoites; limited CNS penetration

Labeled for treatment of skin infections

Use with caution with severe liver or renal dysfunction

AE: esophageal injuries if dry pilled, GI, hypersalivation in cats

Question 2

Lincomycin

Answer 2

Bacterial static or cidal depending on concentration and susceptibility; when bacteriocidal concentrations are reached, clindamycin exhibits time-dependent killing
Effective against many anaerobes, gram positive aerobic cocci, toxoplasma; excellent activity against staphylococci and streptococci; ineffective against gram negative bacteria

Binds to 50S ribosomal subunit, inhibiting peptide bond formation and protein synthesis of the bacterial cell wall

has activity against a variety of protozoal organisms, but not effective against tachyzoites; limited CNS penetration

Use with caution with severe liver or renal dysfunction

AE: esophageal injuries if dry pilled, GI, hypersalivation in cats
Hypotension and cardiopulmonary arrest if given rapid IV