limbic system + basal ganglia diseases(dr driscoll) Flashcards
what causes parkinsons
death of neurons in substantia nigra (cant produce dopamine)
how many ppl have parkinsons in usa
1 million
symptoms of parkinsons (5)
- hypokinesia (less movement)
- bradykinesia (slow movement)
- difficulty starting/stopping movements
- resting tremor
- muscle rigidity
treatements for parkinsons
- L-dopa
- DBS (deep brain stimulation) targeting GPi and/or STN
dbs works well when surgury goes well but also wares off in effectivness as time goes on (kills cells)
what causes/is huntingtons disease
genetic disease that effects basal ganglia (specifically GABA + enkephilon)
LOTS of ‘loosing bids’ getting through thalamus (cant inhibit unwanted actions)
symptoms of huntingtons
- cant inhibit unwanted movement (constantly moving/cant stop moving) aka athetosis (slow, rythmic, writhing behaviors)
- chorea/chorieform movement (dance-like movement)
dammage to STN from stroke causes
hemibalism (random throwing/thrashing of limbs, usualy arm)
procedural (muscle) memory (def)
motor memmory engrained through practice, unconcious memories (mediated by basal ganglia NOT hippocampus)
what general system controls implicit/non-concious things
limbic system
what makes up the limbic system (8ish)
- singulate gyrus
- intralimbic gyrus
- fornix + inner arc
- hippocampus
- amygdala
- stria terminalis
- bed nucleus of stria terminalis (anxiety)
- habenula
what makes up the limbic gyrus (2)
singulate gyrus and amygdala
what makes up the intralimbic gyrus (2)
stria terminalis and indusium griseum,
what did paul ekman think
facial expressions were the same accross all cultures/groups of people
where/what structures become particuarly active when ostrasized/socially rejected
dACC, subACC, and interior insula
7 main emotions
- anger
- contempt
- discust
- fear
- happiness
- sadness
- suprise