Limbic System Flashcards
Which structure is part of Papez Circuit?
a. cingulate
b. inferior pareital lobule
c. amygdala
d. septal region
a. cingulate
Which is the main feature of Kluver Bucy Syndrome?
a. increased oral activities
b. placidity
c. hypersexuality
d. all of the above
d. all
Which structure is correctly matched to the tract?
a. cingulate gyrus and ventral amygdalofugal pathway
b. entorhinal cortex and strai terminalis
c. hippocampus and fornix
d. amygdala and corpus callosum
c
What is the function of the limbic system?
HOME- homeostasis, olfaction, memory, emotion
links visceral states and emotion to cognition and behavior
Describe Papez Circuit
Hippocampus> fornix>mamillary bodies>mammilothalamic tract>ant. thalamus> cingulate gyrus>
What else does the limbic system contain ?
septal area, orbitofrontal cortex, nucleus accumbens (pleasure), amygdala (emotion/fear), insula, entorhinal cortex (smell)
Function of the orbital frontal lobe
personality, behavior control, and self awareness
What does the cingulate cortex function in rostally and caudal?
Rostral: emotions and motor
Caudal: visual spatial and memory
Which area of the limbic system is involved in the preservation of self, emotion, aggression sexual behavior, affect of faces, etc.?
amydala
What is the septum involved in?
preservation of species- sexual behavior
What tract connects the amygdala to the hypothalamus and septum?
stria terminalis
The ventral amydalofugal pathway connects the amygdala to what structures?
hypothalamus and brainstem nuclei
What is the perforant path?
entorhinal cortex to dentate (hippocmapus)
Major projection between hippocampus and mammillary body?
fornix
Where does the anterior thalamus project to?
orbitofrontal and cingulate gyrus
What connects the ant. temporal lobe to the orbital and polar frontal cortex?
uncinate fasiculus
What types of receptors are found in high density throughout the limbic system?
cholinergic and opiate receptors
Which virus has high affinity for the limbic system regions?
Herpes Enchephalitis
Temporo-Amygdala-Orbitofrontal Network
integrates visceral sensation and emotion with memory and behavior
Hippocampal-dienchphali and parahippocampal-retrospelnial network what would a lesion cuase
memory and spatial orientation
amnesia and memory disorders
Default Mode Network
Autbiographical memory, introspection
What are the symptoms of Kluver- Bucy Syndrome (bilat temporal lob lesiosn including amygdala, hippocampus and uncus)?
Increased oral activity (no smell)
Hypersexual
Hypermetamophosis (overreaction to visual stimuli)
Placidity (flat affect)
Visual agnosia (loss of recognition of objects)
Bulimia
A friend tells you that her husband had become obsessed with writing about philosophy and is constantly going on retreats alone to think and write about his philosophical ideas. She says he has also been very talkative on the phone and will not hang up for hours when they talk. What might be going on?
Geschwind Syndrome: sensory limbic hyper connection and strengthening of synaptic connections
or interictal personality..
What would a lesion in the amygdala cause?
tameness/reduced emotionality and lack of social interaction
Orbital Frontal syndrome
disinhibited, lack of care about oneself
Frontal/Convexity or Dorsolateral Syndrome
apathetic, automated
Medial Frontal syndrome
akinetic mutism, inert, no drive
What is declarative memory? What is episodic vs semantic?
episodic- personal life events
semantic- facts remembered
What comprises the hippocampal formation?
hippocampus, dentat gyrus, subiculum
Major efferent of the hippocampal formation?
fornix
Major afferent of the hippocampal formation?
perforant path - connects entorhinal cortex to dentate
Which brain region could you stimulate to increase sexual drive, what may be a consequence?
septal region, person may and increased rage or irritability as well
what are the most pleasurable regions in the brain?
Lateral hypothalamus and medial forebrain bundle (connects to septum)
What is one explanation for the addictiveness of heroin or cocaine?
excess dopamine in the mesolimbic system and nucleus accumbens involvement
If a person feels pain and has rage, strong aversive reactions and long lasting hyperemotionality where might the lesion be?
ventromedial nucleus of the hypothalamus
Which area is associated with OCD and sociopathy
cingulus
Tourettes syndrome deals with abnormalities of what?
anterior cingulate- affective vocalizations, coordinated movement
