Limbic System

Question 1

What is the pathway you cannot forget in the limbic system?

Answer 1

hippocampus –> amygdala

Amy is running away from the hippo

Question 2

What is synthesized in the locus ceruleus?

Answer 2

NE

Question 3

What is synthesized in the raphe nuclei?

Answer 3

5HT

Question 4

What is the function of 5HT in the mesolimbic system?

Answer 4

reward brain areas

Question 5

What is the mechanism of cocaine and amphetamine additions?

Answer 5

block dopamine reuptake

remember they also block NE reuptake, act as tests for sympathetic nervous system

Question 6

Lesion of ventral tegmental area or nucleus accumbans may

Answer 6

decrease drug seeking behavior

Question 7

What agonist/antagonist do you use to treat drug addiction?

Answer 7

dopamine antagonists

Question 8

Neurons of this type are lost in Alzheimer disease

Answer 8

cholinergic

Question 9

This part of the brain is involved in fear conditioning

Answer 9

amygdala

Question 10

Lesioning of the amygdala prevents this type of conditioning

Answer 10

fear conditioning

Question 11

The prefrontal cortex normally has this effect on the amygdala

Answer 11

inhibition

Question 12

What happened to patient HM?

Answer 12

bilateral medial temporal lobectomy (hippocampus)

Question 13

What is the difference between explicit and episodic memory?

Answer 13

explicit: can say something one remembers
episodic: “motor memory,” can recall and replicate movements

Question 14

Urbach-Wiethe disease is impaired recognition of facial emotions due to lesioning of

Answer 14

amygdala

Question 15

PTSD is caused by

Answer 15

increased amygdala activity

Question 16

Schizophrnia is caused by dysreguation of

Answer 16

either 5HT or Glu or both

Question 17

Haloperidol mechanism

Answer 17

dopamine antagonist

Question 18

Haloperiodol side effects

Answer 18

Parkinson-like symptoms

Question 19

Clozapine mechanism

Answer 19

dopamine antagonist but with quick “off” period, does not bind to receptor long enough to cause side effects

also blocks glutamate reuptake

Question 20

Phencyclidine

Answer 20

NMDA antagonist

Question 21

2 important antidepressant categories

Answer 21

1. tricyclics

2. SSRIs

Question 22

Tricyclic antidepressant mechanism

Answer 22

block NE and 5HT reuptake

Question 23

SSRI mechanism

Answer 23

block 5HT reuptake

Question 24

Korsakoff Syndrome deficiency

Answer 24

thiamine (B1)

Question 25

Kluver-Bucy syndrome

Answer 25

hypersexuality and oral tendencies

bilateral temporal lobe damage