Lifespan Considerations Flashcards
Category A drug
no risk to fetus
B drug
no risk to animal fetus; info for humans not available
D drug
possible fetal risk (potential benefit vs. risk)
X drug
fetal abnormalities reported & positive evidence of fetal risk in humans. Do not use for pregnant women
Considerations for older adults
- decline in organ function
- drug therapy results in adverse effects/toxicity
- High use of meds
- Noncompliance, non-adherence
Polypharmacy
use of 4 or more medications throughout day
Absorption Gastric pH is Gastric emptying is...bc BF is absorptive surface is
less acidic
slowed bc decreased muscle tone & activity
reduced
reduced
Distribution what happens? (3 things)
- Lower total body water percentages
- Increased fat content
- Decreased production of proteins by the liver, decreased protein binding
Metabolism what happens?
- produces fewer microsomal enzymes
2. Reduced blood flow to liver
Excretion
- Decreased glomerular filtration rate
- Decreased number of nephrons (in kidneys)
DRUGS ARE LESS EFFECTIVE BC OF DECREASED EXCRETION
Confusion, constipation, urinary retention, vomiting, respiratory depression, falls
OPIODS
Edema, nausea, gastric ulceration, bleeding, renal toxicity
NSAIDs
Major & minor bleeding episodes, many drug interactions, dietary interactions
Anticoagulants (heparin, warfarin)
Blurred vision, dry mouth, constipation, confusion, urinary retention, tachycardia
Anticholinergics
Nausea, hypotension, diarrhea, bradycardia, ♡ failure, impotence
Antihypertensives