Lichen Planus Flashcards
What is lichen planus?
Lichen means tree moss
Planus means flat
Flat topped skin rash which is immune mediated disorder
It can affect the mucous membranes
Dermoepidermal junction is _________ waved
Smooth waved
Pathogenesis of lichen planus
Normal healthy keratinocytes present antigens by MHC-1. Cytotoxic T cells kill them and this then starts to spread from stratum basale to stratum granulosum. Keratinocytes start to proliferate and increase in size called Hypergranulosis
Drugs that trigger lichenoid reaction
Antimalarial drugs
Symptoms of Lichen planus
Cutaneous LP
Oral LP
Both LP
6 Ps
Wickham Striae
6 Ps
Planar
Pruritic
Purple
Papular (<5 mm)
Plaque (>5 mm)
Polygonal
Diagnosis of LP
Saw tooth
Hypergranulosis
Appearance
Treatment of LP
Corticosteroids
Remove the triggering factor in lichenoid rxn