LFTS Flashcards
If your AST + ALT have a marked increase >1000, What does this normally signify? [TIA}
- Toxin/drug induced or acute viral hepatitis
* Liver ischaemia
If your ALT + AST have a moderate increase ~300 - 500, What does this normally signify? [AABC]
- Chronic/alcoholic/autoimmune hepatitis
* Biliary obstruction
If your AST + ALT have a mild rise <300, what could this signify? [CHIN]
- Cirrhosis
- Non alcoholic fatty liver disease
- Hepatocellular carcinoma
- Haemochromatosis/ Wilson’s
If your ALP has a marked increase (>4 X normal), What does this normally signify?
• Cholestasis → Gallstones eg.
If your ALP has a moderate increase (<3x normal), what does this normally signify?
• Hepatitis, cirrhosis, infiltration
What does GGT do to confirm if rise in ALP is of hepatic origin?
It mirrors ALP.
What does a rise in GGT signify?
Raised with alcohol abuse and enzyme inducing drugs
What is a rise in unconjugated bilirubin symptomatic of?
- Increased RBC breakdown
- Impaired hepatic uptake
- Impaired conjugation
What is a rise in conjugated bilirubin symptomatic of?
- Hepatocellular dysfunction
* Impaired hepatic secretion
If you have ↓albumin ↓protein, what is this symptomatic of?
- Advanced cirrhosis,
- alcoholism,
- protein malnutrition,
- chronic inflamation,
- renal/gut/skin loss
If you have ↓albumin but normal protein, what is this symptomatic of?
infection
If you have ↓ albumin but ↑ protein, what is this symptomatic of?
Myeloma
What is prothrombin time/INR dependent on?
Vit K dependent clotting factors and fibrinogen. → all made in the liver
what is a raised INR symptomatic of?
- Liver disease
- Vit K deficiency
- Consumptive coagulopathy
What is a raised urea symptomatic of?
- Dehydration,
- GI bleed,
- increased protein breakdown,
- high protein intake
- drugs
