LFTs Flashcards
What are tested in LFTs?
- Protein
- Albumin
- Bilirubin
- ALT
- AST
- GGT
- ALP
For GGT, ALP, AST, ALT and LD, which are membrane derived and which are derived from the cytoplasm?
ALP and GGT are from membrane
AST, ALT and LD are from the cytoplasm
Where else can you find AST?
mitochondria
What is normally raised in biliary disease? e.g. gallstones
ALP and GGT
What do we normally see in alcoholic induced liver damage? in regards to LFT
raised GGT because alcohol induces GGT
What do we see in the LFT that may indicate liver necrosis?
Raised ALT, AST, LD
Where else is ALP found?
Bone, placenta
What is the AST and ALT halflife?
AST= 18 hrs; ALT= 36 hrs
what does AST>ALT usually indicate? and ALT> AST?
AST>ALT–> may indicate acute alcohol/toxin injury
ALT> AST may indicate chronic condition
Which of the LFTs is liver specific?
ALT
What is ALTs normal role?
Converts alanine to pyruvate in the CORI cycle
What does an ALT level of 5000 mean?
1/2 of the liver has died
What is the normal role of AST?
Converts aspartate and glutamate to oxaloglutarate and oxaloacetate in the KREB cycle
AST in the cytoplasm and mitochondria helps with oxaloacetate transfer into the mitochondria.
What will be the difference in GGT and ALP in intrahepatic biliary obstruction and extra hepatic biliary obstruction?
Intrahepatic= GGT + ALP + Extrahepatic= GGT +++ ALP +++
What are some drugs that can harm the liver?
Statin, anti-epileptic drugs, ethanol, paracetamol, antibiotics, allopurinol
