Leys - Drug Resistance

Question 1

Drug metabolism can take place anywhere in the body (_______, _______, _______, _______) but _______ is the prime site.

Answer 1

plasma
kidney
lung
gut wall
liver

Question 2

There are three potential outcomes of drug metabolism:

1. _______
2. _______
3. _______

Answer 2

1. increase in drug hydrophilicity and ability to be excreted (hepatic)
2. metabolic products are less pharmacologically active than the substrate drug
3. inactive prodrugs converted to their active forms (hepatic)

Question 3

There are several mechanisms of drug resistance including:

1. _______
2. _______
3. _______
4. _______
5. _______

Answer 3

1. decreased permeability
2. alteration of the target site for the drug
3. enzymatic inactivation of the drug
4. active transport of the drug out of the cell
5. amplification of the gene coding for the target of the drug

Question 4

A _______ in DNA repair activity can _______ effectiveness of drugs that target DNA.

Answer 4

increase

decrease

Question 5

_______ results from a increase in the amount of _______ that can pump many different drugs out of the cell.

Answer 5

mulitdrug resistance

transporter proteins