Leys - Drug Resistance Flashcards
1
Q
Drug metabolism can take place anywhere in the body (_______, _______, _______, _______) but _______ is the prime site.
A
plasma kidney lung gut wall liver
2
Q
There are three potential outcomes of drug metabolism:
- _______
- _______
- _______
A
- increase in drug hydrophilicity and ability to be excreted (hepatic)
- metabolic products are less pharmacologically active than the substrate drug
- inactive prodrugs converted to their active forms (hepatic)
3
Q
There are several mechanisms of drug resistance including:
- _______
- _______
- _______
- _______
- _______
A
- decreased permeability
- alteration of the target site for the drug
- enzymatic inactivation of the drug
- active transport of the drug out of the cell
- amplification of the gene coding for the target of the drug
4
Q
A _______ in DNA repair activity can _______ effectiveness of drugs that target DNA.
A
increase
decrease
5
Q
_______ results from a increase in the amount of _______ that can pump many different drugs out of the cell.
A
mulitdrug resistance
transporter proteins