Lewis System Flashcards
1
Q
Genes: LeLe and Sese Le antigens:____
A
Le antigens: Le^a and Le^b
2
Q
Genes LeLe and sese Le antigens:___
A
Le^a
3
Q
Genes lele and SeSe Le antigens:___
A
none (H antigens)
4
Q
the secretor gene( Se FUTZ gene) codes for an enzyme that adds fucos to the ____
A
terminal Galactose
5
Q
The Le gene (FUT3 gene) codes for an enzyme that codes for an enzyme that adds fucose to the ____
A
subterminal GLcNAc
6
Q
newborns are born with Le(a__b__) on there RBC’s then transition for Le(a__b__)
A
Le(a-b-)
Le(a+b+)
7
Q
what class of immunoglobulin are Lewis antigens?
A
IgM
8
Q
enzymes that change the Ag expression or Ab binding are called
A
proteolytic enzymes
9
Q
true or false
Lewis antibodies are naturally occuring
A
true
10
Q
which Lewis antibody has variants?
A
anti-Le^b
11
Q
why does the Lewis system not really matter for HDFN?
A
- Lewis antibodies are primarily IgM (cant cross the placenta)
- baby red cells are Le(a-b-)
