Chapter 1

Question 1

Additive: Dextrose

Answer 1

Supports ATP generation

Question 2

Additive: Adenine

Answer 2

Provides Substrate from RBCs can synthesis ATP

Question 3

standard unit size of blood?

Answer 3

450 ml of blood (+ 45 ml)

Question 4

how much anticoagulant is added to standard unit of blood?

Answer 4

63 mls

Question 5

additives: Dextrose

Answer 5

supports ATP generation by glycolytic pathways

Question 6

additives: Adenine

Answer 6

provides substrate from which RBCs can synthesize ATP

Question 7

additives: Citrate

Answer 7

prevents coagulation by chelating calcium

Question 8

additives: Phosphate

Answer 8

prevents pH from falling excessively

Question 9

additives: Mannitol

Answer 9

carbohydrate used as osmotic diuretic (reduces hemolysis)

Question 10

CPDA-1 preseves blood for how many days?

Answer 10

35 days

Question 11

ACD, CPD, CP2D preserves blood for how many days?

Answer 11

21 days

Question 12

what is AS-1 AS-3 and AS-5?

what do they provide?

Answer 12

• preservatives for packed RBC’s

- provides 42 day storage

Question 13

major function of: EMP

Answer 13

ATP production

Question 14

major function of: Pentose Phosphate Pathway

Answer 14

• produce(NADPH) from glucose metabolism

- produce (6PGD) protect blood cell from oxidative damage

Question 15

major function of: Methemoglobin Pathway

Answer 15

-Maintain Iron in Ferrous form (Fe2+)

Question 16

major function of: Luebering- Rapaport Pathway

Answer 16

-Regulate 2-3 DPG

Question 17

if a person can donate blood every 8 weeks, how long does it take for fluid and RBCs to be replenished

Answer 17

Fluid- 24hrs

RBC’s- 1-2 months

Question 18

what is the shelf life for whole blood?

Answer 18

21-42 days at 1-6C

Question 19

how long can blood be frozen for?

Answer 19

10 years

Question 20

what is the cryoprotective agent?

Answer 20

glycerol

Question 21

what is is PIPA solution used for?

Answer 21

rejuvenation of RBCs