Chapter 1 Flashcards
Additive: Dextrose
Supports ATP generation
Additive: Adenine
Provides Substrate from RBCs can synthesis ATP
standard unit size of blood?
450 ml of blood (+ 45 ml)
how much anticoagulant is added to standard unit of blood?
63 mls
additives: Dextrose
supports ATP generation by glycolytic pathways
additives: Adenine
provides substrate from which RBCs can synthesize ATP
additives: Citrate
prevents coagulation by chelating calcium
additives: Phosphate
prevents pH from falling excessively
additives: Mannitol
carbohydrate used as osmotic diuretic (reduces hemolysis)
CPDA-1 preseves blood for how many days?
35 days
ACD, CPD, CP2D preserves blood for how many days?
21 days
what is AS-1 AS-3 and AS-5?
what do they provide?
- preservatives for packed RBC’s
- provides 42 day storage
major function of: EMP
ATP production
major function of: Pentose Phosphate Pathway
- produce(NADPH) from glucose metabolism
- produce (6PGD) protect blood cell from oxidative damage
major function of: Methemoglobin Pathway
-Maintain Iron in Ferrous form (Fe2+)
major function of: Luebering- Rapaport Pathway
-Regulate 2-3 DPG
if a person can donate blood every 8 weeks, how long does it take for fluid and RBCs to be replenished
Fluid- 24hrs
RBC’s- 1-2 months
what is the shelf life for whole blood?
21-42 days at 1-6C
how long can blood be frozen for?
10 years
what is the cryoprotective agent?
glycerol
what is is PIPA solution used for?
rejuvenation of RBCs
