Leukocytosis

Question 1

4 primary marrow disorders where we see neutrophilia?

Answer 1

CML, other proliferative disorders, sickle cell, neurotrophilic leukemia.

Question 2

6 common causes of secondary neutrophilia?

Answer 2

Infection, inflammation, stress, smoking, aplenia and meds.

Question 3

What 4 drugs/meds to remember that will cause neutrophilia?

Answer 3

Lithium, corticosteroids, epinephrine, and GCSF.

Question 4

What are 3 most common types of infection causing a rise in neutrophils?

Answer 4

Bacterial, pyognenic
Mycotic
Rickettsial

Question 5

What 2 patient populations to remember that can have a mild increase in neutrophils and why?

Answer 5

Smoking and obese because of an underlying inflammatory state.

Question 6

What are the 4 different pools of neutrophils and explain demmargination of neutrophils?

Answer 6

Bone marrow, marginated, circulating, and tissue.
Vigorous exercise or stress releases catecholamines and cortisol which basically knock neutrophils attached to the vessel wall into the blood, increasing the neutrophil count.
See this big time in the Pulmonary circulation.

Question 7

2 big time malignancies causing chronic neutrophilia?

Answer 7

Gastric and bronchogenic

Question 8

Lets say patient has high neutrophil count, what would make us go straight to bone marrow examination?

Answer 8

If there is leukosrythroblastic smear

Question 9

What patients are we trying to identify for serious pathology associated with eosinophilia?

Answer 9

Greater than 1500 cells or evidence of end organ disease

Question 10

What 6 things should be included in the history for a patient with high eosinophils?

Answer 10

B symptoms, rash, diarrhea, allergic symptoms, travel history and food intake.

Question 11

What kind of infections are most commonly causing high eosinophils and give a specific example and the 4 symptoms you will commonly see?

Answer 11

Parasites
T spiralis from a pig
Eosinophilia, periorbital edema, myositis, and fever

Question 12

What is the most common cause of eosinophilia in underdevelopinng countries?

Answer 12

Helminth infections

Question 13

5 allergic conditions leading to high eosinophils?

Answer 13

Allergic rhinitis, atopic dermatitis, angioedema, fungal allergy, and asthma

Question 14

3 medications that can cause eosinophilia?

Answer 14

Antibiotics, NSAIDS, and antipsychotics

Question 15

What respiratory tract condition can lead to high Es?

Answer 15

Bronchiectasis