Clotting Disorders

Question 1

What is the inheritance pattern of protein c and protein s deficiency?

Answer 1

C is autosomal recessive

S is autosomal dominant

Question 2

What is the inheritance of antithrombin deficiency?

Answer 2

Autosomal dominant

Question 3

What are the top 5 inherited clotting diseases?

Answer 3

Factor 5, prothrombin gene mutation, antithrombin def., protein c def., protein s def.

Question 4

What is the most common form of acquired thrombopilia?

Answer 4

APS

Question 5

What is going on with the lupus anticoagulants/APS antibodies as far as PT and PTT and mixed study?

Answer 5

Times are prolonged and the mix study does not correct the times because these are antibodies/inhibitors

Question 6

What can antiphospholipid antibodies do sometimes as well?

Answer 6

Attack beta 2 microglobulin which inhibits coagulation and platelet aggregation

Question 7

2 options for treating clotting disorders?

Answer 7

Lifelong anticlot treatment

Only use it in high risk situations like surgery, etc.

Question 8

What does the ACCP recommend regarding anticoagulation in patients with favor 5 mutation or prothrombin mutation?

Answer 8

Discontinue anticoagulation after 3-6 months