Bleeding Disorders Flashcards
What test has replaced the bleeding time test for platelets?
Platelet function screening which measures the ability of activated platelets treated with collagen and epi to, in vivo, to do their thing
What does the thrombin time measure?
Time it takes to go from fibrinogen to fibrin clot.
According to him, what is the most common cause of abnormal platelet function?
Aspirin and NSAIDS
What 4 families of drugs mess with secondary hemostasis?
Heparin, warfarin, direct thrombin inhibitors, and factor 10 inhibitors.
What is the inheritance and what gender is most commonly affected by the hemophilias?
X linked and males
3 clinical signs of hemophilia 8 or 9?
Childhood hematoma, hemarthrosis and persistent delayed bleeding
What is different about the clinical sign of hemophilia vs. acquired inhibitors?
Soft tissue bleeds in acquired but not bleeding in the joints
What is a sensitive test for liver failure and what happens to the pt and PTT?
Pt
But both PTT and pt will prolong
Two ways to treat vitamin k deficiency?
Oral or subq vitamin k, but will take a day
Fresh frozen plasma if need urgent.
What is the best way to treat an INR over 9?
FFP or recombinant 7
What is the best way to treat an INR between 5 and 9?
Oral vitamin K
What to do if patient is on a vitamin k antagonist and INR less than 5?
Withold the drug
6 things that help us diagnose DIC?
Prolonged pt, PTT, TT, high d dimer, low fibrinogen and platelets
