leukmias

Question 1

RAI staging system is for what?

Answer 1

cll

Question 2

fab is for

Answer 2

AML

but also ALL

Question 3

AUR RODS

Answer 3

found in AML specifally M3 variant

Question 4

which types of leukemias more likley to lead to BM failure

Answer 4

ACUTE because grow rapidly

Question 5

which leukemia has low ALP

Answer 5

CML

Question 6

richters tranformation

Answer 6

is from CLL- devops into a rare b cell lymphoma which is b cell usually

Question 7

definitve tx for leukmemias

Answer 7

allogenic stem cell

Question 8

whats the M3 variant called

Answer 8

ACUTE PROMYLOCYTIC LEUKMEIA

Question 9

what are smudge cells

Answer 9

found in CLL
mature lymphocytes that rupture easily

Question 10

what is rai

stage 1

Answer 10

staging for CLL

looks at lymphadenpathy, anemia, PLT, lymphocyte count, liver and spleen involevemt

4 stages

1. just lymphocytosis

Question 11

stage 2 rai

Answer 11

lymphocytosis and lympahdenppathy

Question 12

stage 3

Answer 12

lymphocytosis
lymphadenopathy +-

enlarged spleen OR liver (but most likely is spleen)

Question 13

stage 4

Answer 13

thrombocytopenia
anemia

Question 14

ALL signs in kids

Answer 14

easy brusising
meningism
testicular enlargement
thymic infiltration - do ct thorax
hepatomspleonmegaly
pale - anemic
epistaxis
bone pain

Question 15

classification of ALL

Answer 15

l1- smallest
l2
l3- looks similar to burkitts lymphoma

Question 16

what’s the most common sign of ALL

Answer 16

lymphadenopathy

Question 17

tumour lysis syndrome

Answer 17

hyperkalemia
hyperuricemia
hyperphospahtemia
hyper ldh

Question 18

why could you possibly see superior vena cava syndrome ?

Answer 18

in ALL, as if can infiltratek the thymus which is in the mediastinum so can compress nearby mediastinal structures

Question 19

unusual presnetaton of hodgkin soemtimes

Answer 19

itchy skin

Question 20

TKI used in

Answer 20

CML

Question 21

tki GENERATIONS - NB

Answer 21

1. imatinib
2. nilotinib + dasatinib
   3.bosutinib

Question 22

7+3 used in

Answer 22

AML except M3 vairant

Question 23

transolactions for AML

Answer 23

M2- 8,21
M3- 15,17

Question 24

why does hodgkins cause itching

Answer 24

1. release of pro inflammatory cytokines and histamine like substances
2. eosiniphila linked with histamin

Question 25

lines of stem cells

Answer 25

lymphoid - b, t , NK myeloids - eveything else

Question 26

wbc classifcation

Answer 26

granuloctyes - eosiniophils, basophils, neutophils, a granuloctyes - b, t, NK , monocytes

Question 27

which type of leukeia is known for affecting b lymohcytes

Answer 27

CLL

Question 28

does leukemia ffect lymph nodes

Answer 28

not all, but the most associsted is CLL

Question 29

for someone to have cll what must they have

Answer 29

lymphocytosis ( RAI )

Question 30

WHICH LEUKEMIA IS MOST ASSOCIATED WITH MASSIVE HSM

Answer 30

CML

Question 31

WHY IS THERE HSM IN LEUKMEIA

Answer 31

1 the sheer amount of wbc accumulating and building up in organs like the spleen 2. due to congestion and stagantion 3. the spleen working hard to remove the dying cells, the liver also takes part in this too,in fact this is why the liver can take over the functions of the spleen so thats why we can live without a spleen