leukmias

Question 1

RAI staging system is for what?

Answer 1

cll

Question 2

fab is for

Answer 2

AML

Question 3

AUR RODS

Answer 3

found in AML specifally M3 variant

Question 4

which types of leukemias more likley to lead to BM failure

Answer 4

ACUTE because grow rapidly

Question 5

which leukemia has low ALP

Answer 5

CML

Question 6

richters tranformation

Answer 6

is from CLL- devops into a rare b cell lymphoma which is b cell usually

Question 7

definitve tx for leukmemias

Answer 7

allogenic stem cell

Question 8

whats the M3 variant called

Answer 8

ACUTE PROMYLOCYTIC LEUKMEIA

Question 9

what are smudge cells

Answer 9

found in CLL
mature lymphocytes that rupture easily

Question 10

what is rai

stage 1

Answer 10

staging for CLL

looks at lymphadenpathy, anemia, PLT, lymphocyte count, liver and spleen involevemt

4 stages

1. just lymphocytosis

Question 11

stage 2 rai

Answer 11

lymphocytosis and lympahdenppathy

Question 12

stage 3

Answer 12

lymphocytosis
lymphadenopathy +-

enlarged spleen OR liver (but most likely is spleen)

Question 13

stage 4

Answer 13

thrombocytopenia
anemia

Question 14

ALL signs in kids

Answer 14

easy brusising
meningism
testicular enlargement
thymic infiltration - do ct thorax
hepatomspleonmegaly
pale - anemic
epistaxis
bone pain

Question 15

classification of ALL

Answer 15

l1- smallest
l2
l3- looks similar to burkitts lymphoma

Question 16

what’s the most common sign of ALL

Answer 16

lymphadenopathy

Question 17

tumour lysis syndrome

Answer 17

hyperkalemia
hyperuricemia
hyperphospahtemia
hyper ldh

Question 18

why could you possibly see superior vena cava syndrome ?

Answer 18

in ALL, as if can infiltratek the thymus which is in the mediastinum so can compress nearby mediastinal structures

Question 19

unusual presnetaton of hodgkin soemtimes

Answer 19

itchy skin

Question 20

TKI used in

Answer 20

CML

Question 21

tki GENERATIONS - NB

Answer 21

1. imatinib
2. nilotinib + dasatinib
   3.bosutinib

Question 22

7+3 used in

Answer 22

AML except M3 vairant

Question 23

transolactions for AML

Answer 23

M2- 8,21
M3- 15,17

Question 24

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