leukemia disorder Flashcards
- are generalized neoplastic proliferation or
accumulation of leukopoietic cells with or without
involvement of the peripheral blood.
LEUKEMIAS
based on natural history
Chronologic
the most common form of leukemia in children
characterized by a rapid increase in the numbers of
immature blood cells
Acute Leukemia
characterized by the excessive build up of relatively
mature, but still abnormal, white blood cells
- mostly occurs in older people, but can theoretically
occur in any age group
Chronic Leukemia
lasting from two to six months or even twelve
months
Sub-acute Leukemia
a type of myeloblastic leukemia
formation of tumors originating from periosteum,
especially of skull, orbits, nasal sinuses, ribs and
vertebrae
Chloroma
a focal malignant tumor composed of myeloblast
or early myeloid precursors occurring outside of the
bone marrow
Myeloblastoma
local tumorous proliferation of plasma cells in the
marrow
Myeloma
presence of immature or abnormal cells with WBC
count greater than 15 x 10⁹/L
Leukemic Leukemia
with immature or abnormal cells in peripheral
blood and with WBC count less than 15 x 10⁹/L
Subleukemic Leukemia
with no immature cells in the peripheral blood and with WBC count less than 15 x 10⁹/L
Aleukemic Leukemia
is a reactive but excessive leukocytosis
characterized by the presence of immature cells in
the peripheral blood vessels
Leukemoid Reactions
group of neoplasms characterized by proliferation of
myeloid tissue and elevation in one or more myeloid
cell type in the peripheral blood
Myeloproliferative Disorders
other name of Myelofibrosis
Myeloid Metaplasia
hematopoietic cells is the
Philadelphia
chromosome
are group of clonal disorder of neoplastic
pluripotential stem cells characterized by a decrease
in one or more types of peripheral blood cells due to
abnormal maturation in the bone marrow
Myelodysplastic syndrome
represent a group of neoplastic conditions
originating from cells of the lymphoreticular system
Lymphoproliferative Disorders
composed of small B-lymphocytes with abundant cytoplasm and fine cytoplasmic projections
Hairy Cell Leukemia
Classical Hodgkin lymphoma
Hodgkin’s Disease
a malignant disorder characterized by painless,
progressive enlargement of lymphoid tissue
Hodgkin’s Disease
nucleus bearing a very large nucleolus
Reed-Sternberg Cell
has an “owl’s eye”
appearance or popcorn appearance
Reed-Sternberg
represent a group of diseases with abnormal
proliferation of mesenchymal cells that are closely
related to phagocytic histiocytes and to fat cells
Storage Disease
other name of Multiple Myeloma
Plasmatocytoma
Kohler’s Disease
is a neoplasmic proliferation of morphologically
abnormal plasma cells primarily occurring in the BM
either in nodules or diffusely
Multiple Myeloma
is a collagen disease which affects women most
commonly
Systemic Lupus Erythematosus
3 types of Antibody
a. Anti-DNP
b. Anti-DNA
c. Anti-nuclear
a disorder secondary to an infection with the human
immunodefficiency virus (HIV)
Acquired Immunodeficiency Syndrome
a RNA retrovirus that is cytotropic for CD4
positive T cells and macrophages
human
immunodefficiency virus (HIV)
other name of Infectious Mononucleosis
Glandular Fever
Pfeiffer’s Disease
Kissing Disease
based on predominant cell type
cytologic
CYTOLOGIC (BASED ON PREDOMINANT CELL
TYPE
- Granulocytic or Myelocytic Leukemia
- Lymphocytic/Lymphoid Leukemia
- Monocytic Leukemia
- Plasma Cell Leukemia
- Mast Cell Leukemia
- Histiocytic Leukemia
- Megakaryocytic Leukemia
- Basophilic Leukemia
is a neoplastic clonal MPD that commonly
manifests with panmyelosis in the bone marrow and ncreases in RBC, granulocytes, and platelets in the
peripheral blood
polycythemia vera
classified as a MPD in which the proliferation of an
abnormal type of BM stem cell results in fibrosis, or
the replacement of the marrow with collagenous
connective tissue fibers
Myelofibrosis
Characterized by autonomous proliferation of the
megakaryocytic cell lines.
*Thrombocytosis is present without a reactive cause.
Thrombocythemia
