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leukemia disorder 1 Flashcards

1
Q

absolute leukocyte counts >11.0x109
/L

A

Leukocytosis

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2
Q

absolute leukocyte counts <3.0x109
/L

A

leukopenia

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3
Q

the segmentation of neutrophil is greater
than 2-5 lobes

A

Hypersegmented neutrophil

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4
Q

Has a normal size 4-6 lobes in the nucleus found in the
stage of recovery from infection

A

polycyte

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5
Q

Larger than normal neutrophil and has 5-10 nuclear
lobes seen in pernicious anemia, the hypersegmented
neutrophils are one of the hallmark of this condition

A

macropolycyte

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6
Q

Atypical Lymphocyte also known as

A

Virocyte
Downey type cell
Turk Irritation cell

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7
Q

Atypical Lymphocyte can be seen in

A

HIVV
herpes simplex infections
infectious mononucleosis,
viral hepatitis,
viral pneumonia

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8
Q

Atypical Lymphocyte appearance

A

sunny side up
Swiss-cheese
Tunneled appearance
Moth-eaten

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9
Q
  • myelobast that is characterized by having a nucleus with deep
    indentions often suggesting lobulation
A

Rieder cell

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10
Q

Rieder cell seen in

A

acute myeloid leukemia (AML)

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11
Q

signs of degeneration in severe infections, chemical
poisoning and leukemia

cell has holes

A

Vacuolated cell

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12
Q
  • net-like nucleus from a ruptured white cell specially a PMN
A

. Basket cell or Smudge cell

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13
Q

Basket cell or Smudge cell seen in

A

chronic lymphocytic leukemia

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14
Q

Lupus Erythematosus cell also known as

A

Hargraves

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15
Q

PMN which had engulfed the nuclear material of another PMN
or a lymphocyte

A

Lupus Erythematosus

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16
Q

Monocyte with an engulfed nucleus usually of a lymphocyte
or maybe the whole lymphocyte itself

A

Tart Cell

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17
Q
  • exhibits nucleophagocytosis
A

Tart Cell

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18
Q

lymphocyte with hair like cytoplasmic projection surrounding
the nucleus

A

Hairy cell

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19
Q

rough lymph cell with nucleus that is grooved or convulated

A

. Sezary Cell

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20
Q

. Sezary Cell seen in

A

Sezary syndrome and mycosis fungoides

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21
Q

ABNORMAL INCLUSION BODIES IN LEUKOCYTES

A

Dohle - Amato Bodies
Auer bodies/rods
Toxic granules
Russel or Fush’s Bodies
Snapper-Scheid Bodies

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22
Q

are linear or spindle-shaped red-purple inclusions in
myeloblasts and monoblasts

caused by unusual
development of lysozomes

A

Auer bodies/rods

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23
Q

dark blue to purple cytoplasmic granules in the
metamyelocyte, band or in neutrophil stage

A

. Toxic granules

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24
Q

stain blue-gray usually seen in the periphery of the cytoplasm
of neutrophils

A

Dohle - Amato Bodies

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25
characteristics of bacterial infections and are frequently seen in aplastic anemia and also in myelosclerosis
. Toxic granules
26
- remnants of free ribosomes from an earlier stage of development
Dohle - Amato Bodies
27
Dohle - Amato Bodies seen in
bacterial infection, severe burns, exposure to cytotoxic agents and complicated pregnancies
28
- found in the cytoplasm of multiple myeloma and plasma cells after therapy with amidine drugs
Snapper-Scheid Bodies
29
gamma globulins bodies in the cytoplasm of plasma cells and inflamed tissue
Russel or Fush’s Bodies
30
bodies which gave a grape or berry or morula cell appearance
Russel or Fush’s Bodies
31
Not tumor related
Non Neoplastic Disorders
32
Tumor related
Neoplastic and Related Disorders
33
Disorder of nucleus
Hyper-Segmented Neutrophil . Huet Anomaly Pseudo-Pelger-Huet Anomaly
34
Hyper-Segmented Neutrophil Defect of change | Associated Condition | Others
Abnormal DNA synthesis - Megaloblastic Anemia - Shift to the Right
35
Prize-nez appearance Decreased segmentation in neutrophil there’s something wrong with the mutation in the Lamin B.
Huet Anomaly Defect of change
36
CMLS – Chronic myelogenous leukemia MDS – myeloproliferative disorder syndrome
Huet Anomaly Associated Condition
37
Has less dense nuclei with hypogranular cytoplasm
Pseudo-Pelger-Huet Anomaly Defect of change
38
Bums drug reaction infection MDS CML acute leukemia chemotherapy
Pseudo-Pelger-Huet Anomaly Associated condition
39
Alder Reily Anomaly associated condition
hunter's syndrome hurler's syndrome
40
Alder Reily Anomaly defect
accumulation of degraded mucopolysaccharides
41
large peroxidase lysosome inclusion that are deficient in enzyme for phagocytosis
chediak-higashi syndrome defect
42
May-Hegglin Anomaly defect
Dohle-bodies thrombocytopenia, giant pkatelets
43
disorder of cytoplasm
Alder-Reily Anomaly Chediak-Higashi Syndrome May-Hegglin Anomaly Jordan’sAnomaly
44
Functional Disorder
Job’sSyndrome LazyLeukocyte Syndrome Chronic Granulomatous Disease CongenitalC₃ Deficiency Myeloperoxidase Deficiency
45
Gaucher’sDisease defect
deficiency of glucocerebrosidaseenzyme
46
Gaucher’s Disease type I
non-neuronopathic
47
Gaucher’s Disease type II
acute neuronopathic
48
Gaucher’s Disease type III
sub-acute neuronopathic
49
Gaucher’sDisease affects
bone marrow, spleen and liver
50
Niemann-Pick Disease defect
deficiency of sphingomyelinase
51
Schuller-Christian Disease defect
macrophage with cholesterol overload
52
Schuller-Christian Disease associated condition
hyperlipidemia
53
Monocyte-Macrophage disorder
Schuller-Christian Disease Niemann-Pick Disease Gaucher’s Disease
54
Lymphocytes disorders
- Tay-Sachs Disease - Bruton Agammaglobulinemia - Common Variable Hypogammaglobuli- nemia - Nezelof’s Syndrome - Di George’s Syndrome - Swiss-Type Aggamaglobulinemia - Wiscott-Aldrich Syndrome - Ataxia Telangiectasia
55
reduced Ig production in blood
Bruton Agammaglobulinemia
56
deficiency in hexosaminidaseA
Tay-Sachs Disease
57
underdevelopment of the thymus
Nezelof’s Syndrome
58
reduced production of Ig due to overactivity of T8cells
Common Variable Hypogammaglobuli- nemia
59
deletion of a small piece of chromosome 22
Di George’s Syndrome
60
loss of both T and Bcells function
Swiss-Type Aggamaglobulinemia
61
decreased T cellproduction
Ataxia Telangiectasia
62
failure of T-cellresponse -only IgA and IgGare present; IgM is absen
Wiscott-Aldrich Syndrome
63
both random and directed movement of the cells are defective
Lazy leukocyte syndrome
64
random movement of phagocytes is normal but directional motility is impaired
Job's syndrome
65
Intracellular killing mechanism of granulocyte is defective
Chronic Granulomatous Disease
66

HEMA FINALS (7 decks)

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