leukemia disorder 1 Flashcards
absolute leukocyte counts >11.0x109
/L
Leukocytosis
absolute leukocyte counts <3.0x109
/L
leukopenia
the segmentation of neutrophil is greater
than 2-5 lobes
Hypersegmented neutrophil
Has a normal size 4-6 lobes in the nucleus found in the
stage of recovery from infection
polycyte
Larger than normal neutrophil and has 5-10 nuclear
lobes seen in pernicious anemia, the hypersegmented
neutrophils are one of the hallmark of this condition
macropolycyte
Atypical Lymphocyte also known as
Virocyte
Downey type cell
Turk Irritation cell
Atypical Lymphocyte can be seen in
HIVV
herpes simplex infections
infectious mononucleosis,
viral hepatitis,
viral pneumonia
Atypical Lymphocyte appearance
sunny side up
Swiss-cheese
Tunneled appearance
Moth-eaten
- myelobast that is characterized by having a nucleus with deep
indentions often suggesting lobulation
Rieder cell
Rieder cell seen in
acute myeloid leukemia (AML)
signs of degeneration in severe infections, chemical
poisoning and leukemia
cell has holes
Vacuolated cell
- net-like nucleus from a ruptured white cell specially a PMN
. Basket cell or Smudge cell
Basket cell or Smudge cell seen in
chronic lymphocytic leukemia
Lupus Erythematosus cell also known as
Hargraves
PMN which had engulfed the nuclear material of another PMN
or a lymphocyte
Lupus Erythematosus
Monocyte with an engulfed nucleus usually of a lymphocyte
or maybe the whole lymphocyte itself
Tart Cell
- exhibits nucleophagocytosis
Tart Cell
lymphocyte with hair like cytoplasmic projection surrounding
the nucleus
Hairy cell
rough lymph cell with nucleus that is grooved or convulated
. Sezary Cell
. Sezary Cell seen in
Sezary syndrome and mycosis fungoides
ABNORMAL INCLUSION BODIES IN LEUKOCYTES
Dohle - Amato Bodies
Auer bodies/rods
Toxic granules
Russel or Fush’s Bodies
Snapper-Scheid Bodies
are linear or spindle-shaped red-purple inclusions in
myeloblasts and monoblasts
caused by unusual
development of lysozomes
Auer bodies/rods
dark blue to purple cytoplasmic granules in the
metamyelocyte, band or in neutrophil stage
. Toxic granules
stain blue-gray usually seen in the periphery of the cytoplasm
of neutrophils
Dohle - Amato Bodies
characteristics of bacterial infections and are frequently seen
in aplastic anemia and also in myelosclerosis
. Toxic granules
- remnants of free ribosomes from an earlier stage of
development
Dohle - Amato Bodies
Dohle - Amato Bodies seen in
bacterial infection, severe burns, exposure to
cytotoxic agents and complicated pregnancies
- found in the cytoplasm of multiple myeloma and plasma cells
after therapy with amidine drugs
Snapper-Scheid Bodies
gamma globulins bodies in the cytoplasm of plasma cells and
inflamed tissue
Russel or Fush’s Bodies
bodies which gave a grape or berry or morula cell appearance
Russel or Fush’s Bodies
Not tumor related
Non Neoplastic Disorders
Tumor related
Neoplastic and Related Disorders
Disorder of nucleus
Hyper-Segmented Neutrophil
. Huet Anomaly
Pseudo-Pelger-Huet Anomaly
Hyper-Segmented Neutrophil
Defect of change | Associated
Condition | Others
Abnormal DNA synthesis - Megaloblastic Anemia - Shift to the Right
Prize-nez
appearance
Decreased
segmentation in
neutrophil
there’s something
wrong with the
mutation in the
Lamin B.
Huet Anomaly
Defect of change
CMLS – Chronic
myelogenous
leukemia
MDS –
myeloproliferative
disorder syndrome
Huet Anomaly
Associated Condition
Has less dense
nuclei with
hypogranular
cytoplasm
Pseudo-Pelger-Huet Anomaly
Defect of change
Bums
drug reaction
infection
MDS
CML
acute leukemia
chemotherapy
Pseudo-Pelger-Huet Anomaly
Associated condition
Alder Reily Anomaly associated condition
hunter’s syndrome
hurler’s syndrome
Alder Reily Anomaly defect
accumulation of degraded mucopolysaccharides
large peroxidase lysosome inclusion that are deficient in enzyme for phagocytosis
chediak-higashi syndrome defect
May-Hegglin Anomaly defect
Dohle-bodies thrombocytopenia, giant pkatelets
disorder of cytoplasm
Alder-Reily Anomaly
Chediak-Higashi Syndrome
May-Hegglin Anomaly
Jordan’sAnomaly
Functional
Disorder
Job’sSyndrome
LazyLeukocyte Syndrome
Chronic Granulomatous Disease
CongenitalC₃ Deficiency
Myeloperoxidase
Deficiency
Gaucher’sDisease defect
deficiency of
glucocerebrosidaseenzyme
Gaucher’s Disease type I
non-neuronopathic
Gaucher’s Disease type II
acute neuronopathic
Gaucher’s Disease type III
sub-acute neuronopathic
Gaucher’sDisease affects
bone
marrow, spleen
and liver
Niemann-Pick
Disease defect
deficiency of sphingomyelinase
Schuller-Christian
Disease defect
macrophage with cholesterol
overload
Schuller-Christian
Disease associated condition
hyperlipidemia
Monocyte-Macrophage disorder
Schuller-Christian
Disease
Niemann-Pick
Disease
Gaucher’s Disease
Lymphocytes disorders
- Tay-Sachs Disease
- Bruton Agammaglobulinemia
- Common Variable Hypogammaglobuli- nemia
- Nezelof’s Syndrome
- Di George’s Syndrome
- Swiss-Type Aggamaglobulinemia
- Wiscott-Aldrich
Syndrome - Ataxia
Telangiectasia
reduced Ig production in blood
Bruton
Agammaglobulinemia
deficiency in hexosaminidaseA
Tay-Sachs Disease
underdevelopment of the
thymus
Nezelof’s
Syndrome
reduced production of Ig due to
overactivity of T8cells
Common Variable
Hypogammaglobuli-
nemia
deletion of a small piece of
chromosome 22
Di George’s
Syndrome
loss of both T and Bcells
function
Swiss-Type
Aggamaglobulinemia
decreased T cellproduction
Ataxia
Telangiectasia
failure of T-cellresponse
-only IgA and IgGare
present; IgM is absen
Wiscott-Aldrich
Syndrome
both random and directed movement of the cells are defective
Lazy leukocyte syndrome
random movement of phagocytes is normal but directional motility is impaired
Job’s syndrome
Intracellular killing mechanism of granulocyte is defective
Chronic Granulomatous Disease
