Leukaemia - Acute Lymphoblastic Leukaemia

Question 1

Epidemiology of Acute Lymphoblastic Leukaemia (5).

Answer 1

1. Commonest Paediatric Cancer.
2. Peak : Age of 2-4.
3. Also Affects Adults 45+.
4. Association : Down’s.
5. Boys > Girls.

Question 2

Genetics of Acute Lymphoblastic Leukaemia.

Answer 2

Philadelphia chromosome - 9 | 22 Translocation.

Question 3

Types of ALL (3).

Answer 3

1. Commonest - pre-B Phenotype (CD10) (75%).
2. T-Cell (20%).
3. B-Cell (5%).

Question 4

Unique Clinical Feature of Acute Lymphoblastic Leukaemia.

Answer 4

Testicular Swelling.

Question 5

Investigations of ALL (2).

Answer 5

1. Bloods : Pancytopenia.
2. Blood Film : Blast Cells.

Question 6

Management of ALL.

Answer 6

Chemotherapy Regimens.

Question 7

Poor Prognostic Factors of ALL (5).

Answer 7

1. Age < 2 or > 10.
2. WCC > 20 at Diagnosis.
3. T/B Cell-Surface Markers.
4. Non-Caucasian.
5. Male Sex.