Lesture 2

Question 1

How can we test the functioning of the dopamines system?

Answer 1

The protectin challenge test can be performed, which is where you give a dopamine agonist and mass protection levels.

Question 2

What happens when animals receive a reward to dopamine?

Answer 2

Dopamine release is increased this is particularly important in the neucleusaccumbers, which is the terminal of the mesolimbic pathway

Question 3

What are the three noidoparine pathways. Where ale end start ad

Answer 3

Mesolimbic _ from ventralagmenal area (vta) to nucleus accumbens
Meso cortical_ from ventral fagmental area to the cortex (mainly frontal )
And nigrostraital → from male substantia nigra to the dorsal striatum

Question 4

What happens to the work an animal will do when a dopamine antagonist is given (priolide )

Answer 4

The animals will nologer work ( push a lever , ) when the drugs effect the nucleus accumbens

Question 5

What is electrical self stimulation? Where does the electrode need to be?

Answer 5

Electrical self stimulation is where an animal will press a over or other work in orde( to receive stimulation to a particular again in the brain mainly via or the nosolimbic pathway

Question 6

What pathway is important in reward? What experimental models support this?

Answer 6

The mesolimbic pathway is important in reward this is demonstrated by
Domaine release is increased during natural reward in the near dous accumbes
Animals will n to revive a reward ( block a by dopamine antagonists )
Will also work for electrical stimulation of mosolimbic pathway.

Question 7

What areas of the brain villas animal self stimulate

Answer 7

VTA
Median forebrain bundle
Nucleus accumbens Less affective)

Question 8

What electrical factors effect electrical self stimulation

Answer 8

Unsupported under a contain current
More current more press
More frequency more press

Question 9

Howdo drugs affect press late in electrical self stimulation?

Answer 9

Drugs that increase depar-he increase press rate
Degrease by antagonists

Question 10

What occurs if you cut the median forebrain bundle(mesolimbic pathway)

Answer 10

It abolishes pressing

Question 11

What drugs will animals self administer intravenously

Answer 11

Amphetamine ) ethanol cocaine morphine and nicotine

Question 12

What drugs will animals selfadminster into the ventral tag meant area

Answer 12

Morpheire and nicotine

Question 13

What drugs will animals administer locally to the nac

Answer 13

Amphetamine and cocaine

Question 14

What happens if you give antagonists when animals are selfed administering drugs ?

Answer 14

Potentiatedby low do Es ofontagonist ) more presses to outcomplate the antagonist
Abolished by high does as more drug doesn’t overcome agon.3t so animals wont press lever- similar to self stimulation animals will ratter press was than eater drink

Question 15

What evidence is there that dopamine release in the nucleus accumbens signals rewards

Answer 15

Self stimulation and dopamine agonists
Selfstimulation of drugs
Dopamine release in area during rewarding behaviour
Conditional place preference
Drugstrat enhance these hohoviors when gives alone will cause dopamine (close in nucleus a numbers.

Question 16

What evidence he is there that dopamine is linked with addiction?

Answer 16

Increased dopamine increases selfstimulaas selfadinistration show conditioned prefer ne place
Many additive drugs horediffrent machismo of action but all increase in the dopamine nucleus accombens

Question 17

What is the machismo of action for drug addiction

Answer 17

Drugs stimuli mesolimbic dopamine neurone which increases da release attenders accompanies, or increases dopamine at the synapse as in Cochin and amphetamines.