Lecture 1

Question 1

What type of neurotransmitter is dopamine?

Answer 1

Dora mine is amonoamine other include serotonin and noradvennaline

Question 2

What one the levels of dopamine and noradreline in the strairaitum

Answer 2

High levels of dopamine compared to a low bull of noradina’ine

Question 3

What evidence is there that dopamine is a neurotransmitter?

Answer 3

Dopamine stimulates AC (kebabian metal ) 1972 binding site found for dopamine (haloperidol) chebabian 1979

Question 4

How many distant derpanine receptors are there?

Answer 4

There are 5 dompanile receptors D5 to Dl

Question 5

List the steps in dopamine synthesis

Answer 5

Tyrosine uptake from blood) active
Tyrosin converted to L-dopa by tyrosin nehydroxylose (rate limiting steps )
Dopa dear boxylose converts todo ldopa partire dopamine gets into his : das portaged

Question 6

List the steps in the synthesis of noradreative

Answer 6

As with dopamine
Tyrosine
Tyrosine hydroylose
L- dopa
Dopa decarboxylose L
Dopamine
Dopamine beta - hydroxyls
Noradrenaline

Question 7

How is dopamine metabolised? At what parts of the pathway?

Answer 7

Monoamineoxidose B
Breaks down dopamine in two parts of the pathway 1, unrealsed dopamine is broken down into Dopac (this is in Order to control the lag of tyrosietydroxylose down regulation, during down regulation,
Also reuptaked dopamine is broken down into dopac , however 20-70-1 in I o is recycled into vesicles. From there dopac is broken down into HVA which is removed from the cell.

Question 8

Where hereare mono amine neurones located in the brain.

Answer 8

Cell bodies mainly y in the mid and hind brain
There one major projections into the forebrain and hypothalamus along with the spinal cord

Question 9

What are the three main dopamine pathways in the brain

Answer 9

Nigrastriatal
Mesolimbic
Mesocortial

Question 10

What dopamine receptors cue excitatory and which are inhibitory?

Answer 10

D1 like receptors ( D1 and D5) are excitatory
Where as D2 like receptors are inhibitory(d2d3d4)

Question 11

What are some D1 like excitatory agonists

Answer 11

Nonselective → apomorphine → used to treat Parkinson’s

Question 12

What are some D2c inhibitory) agonists

Answer 12

Quinpirole → D2 and D5

Question 13

How does phenylalanine effect dopamine synthesis and storage?

Answer 13

It is a false precursor for tyrostenydrosiylose → and others need to revise lecture

Question 14

What drug blocks the activity of Tyrosine hydroxylase ?

Answer 14

alpha-Methyl-p-tyrosine

Question 15

What drug blocks dopa - decarboxlose?

Answer 15

Benserazide carbidiopa

Question 16

What drug blocks the release of dopamine?

Answer 16

Reserpine ?

Question 17

What drug kills doparinergic neurones?

Answer 17

6- hydroxydoparine (6 6-ohpa) or MPTP

Question 18

How does amantidine effect dopamine signalling

Answer 18

It increases dopamine close as at the synapse

Question 19

How does cocaine effect dopamine signalling

Answer 19

It prevents the reuptate of dopamine

Question 20

How do amphetamines effect dopamine signalling?

Answer 20

It increases release, and disrupts breakdown by monoamine boxidose B and prevents reuptake

Question 21

What drugs interfere with the actions of monoamine oxidase B)_

Answer 21

Amphetamines and selegilline

Question 22

What drug interferes with the effects of catechol-O-methyl transferase?

Answer 22

Tolacapone