Lessons Learned Flashcards
What are platelets?
Platelets are cell fragments and do not have nuclei
What effect does a leak in the distillation apparatus have on boiling point?
Leaks in a distillation apparatus increase surface tension, increasing boiling point
How do you calculate half life?
T1/2 = 0.6931/k
How do you find the change in frequency from two wavelengths?
Convert the wavelengths to frequency and use c = (frequency)(wavelength)
What is the path of sperm?
Epididymis, vas deferens, urethra, vagina, cervix, uterus, fallopian tube
What is a regulatory function of skin?
Skin can regulate body temperature; when skin stand up it traps air in a layer, providing insulation
What does normal spermatogenesis produce?
4 haploid sperm cells
How do people with self-serving biases respond to situational variables?
Individuals experiencing self-serving bias attribute their own negative behaviors to situational variables
What are the components of the knee-jerk response?
sensory neuron, motor neuron
What is drive in the psychodynamic theory?
Drive is a negative state of tension created when needs are not met
How does group polarization affect focus groups?
Group polarization affects attitude towards a topic as when people discuss together their views tend to get more polarized
What are the characteristics of the 4 stages of sleep?
NREM1 has low brain activity and blood pressure, NREM2 has decreased muscle activity and no consciousness of the external environment, NREM3 is deep sleep with regular breathing and slow brain waves, REM is the deepest stage with partial paralysis and vivid dreams
What is anomie?
Anomie describes the alienation that individuals feel when social norms and social bonds are weak
How does the ideal gas law change at high pressures?
At higher than atmospheric pressure the volume of gas particles in not negligible
Why can light travel long distances without dimming?
Internal reflection allows light to be carried long distances with little amplitude loss, it can propagate forever if nothing absorbs it
What happens when a basic salt is in an aqueous solution?
The anion of a basic salt reacts with water to produce hydroxyl ions
How do you calculate moles given the mass of a compound?
To find the number of moles in a reaction: grams/molar mass
Why do transition metals change colors?
When electrons in lower energy d orbitals absorb visible light they move to the higher energy d orbitals, causing energy absorption that turns solutions a certain color
How does hydrogen bonding effect stereoisomers?
Hydrogen bonding can make stereoisomers have different stability
What is an equation for buoyancy?
F_b = ρ * V * g
How is density related to depth and pressure?
The pressure in a liquid due to the gravitational force of the liquid above a given depth is proportional to the density and the depth
How is pressure related to velocity in a fluid carrying pipe?
The pressure of a liquid in a pipe is greatest where the fluid velocity is lowest
How does Ohms law relate current and resistance of parallel resistors?
Currents in parallel resistors are inversely proportional to their individual resistances because they have the same voltage drop across them
How can you find blood pressure in different parts of the body?
Blood pressure in the body can be determined by rgh and is independent of blood flow or viscosity
How does pKa magnitude relate to acidity?
A smaller magnitude pKa is more acidic but when pKas are negative a greater pKa is more acidic
What is the distance from crest to trough?
The distance from crest to trough is half the wavelength
When the angle is less than 45 degrees what is the relationship between x and y
When theta is less than 45 degrees, x is greater than y
How do mass affect range?
When air resistance is negligible, mass does not affect range
How does height affect range?
Dropping an object from a higher height increases the airtime and thus the range, range increase by sqt of height
Where is the electron density in a sigma bond?
In sigma bonds most of the electron density is between the nuclei
Are single or double, substituted or unsubstituted bonds stronger?
Double bonds are stronger than single bonds, substituted bonds are stronger than unsubstitued ones
How does decreasing the number of hydrogen bonds in a solution effect the absorbance peak for the O-H bond?
Decreasing the number of hydrogen bonds sharpens the O-H absorbance peak and shift the value to a higher wave number
When is a molecule square planar?
Square planar shape occurs when the central atom has two lone pairs and four bonds
How does lone pair-ligand repulsion change the shape of a molecule?
Lone pair-ligand repulsion increases the angle between a lone pair and a bond with the central atom
Why can’t halides be reduced?
Because a halide has a -1 oxidation state it cannot be further reduced
How do you find the number of valence electrons on a central atom?
When finding the number of valence electrons for a central atom bonded electrons count as 2 and lone pairs count as 2
Why are rigid surfaces used in photoelectric experiments?
Rigid surfaces have more surface area so they can absorb more photons
What is terminal velocity?
Terminal velocity is the velocity of an object when its acceleration goes to zero
How does increasing initial velocity affect terminal velocity?
A greater initial velocity causes an object to reach terminal velocity faster but the terminal velocity is the same
What properties of an object does terminal velocity depend on?
Terminal velocity depends on an objects shape, mass, and area
How is mass and area affected when water changes form?
When water turns into another form the mass stays the same but the area may change
How can you deal with two torques on the same side of the fulcrum?
Torque on the same side of the fulcrum can be added to determine the total torque on that side
How are translational and rotational motion affected when the fulcrum is moved away from the center of mass?
When the fulcrum is no longer at the center of mass forces on the rod cause it to accelerate and have translational and rotational motion
Do the fulcrum exert a force or torque on a rod?
A fulcrum exerts a normal force on the rod but no torque because there is no lever arm
Can an object be in motion if its net torque and force are zero?
If the net force and net torque on an object are both zero the object may still be in motion
What kind of reaction produces a racemic mixture?
If the specific rotation is zero the mixture is racemic so it was produced from an Sn1 reaction
For what type of reaction is the rate determined by the nucleophile?
Sn2 reaction rates are determined by the nucleophile
What is the priority order of single, double, and triple bonds
Double bonds are higher priority than single bonds, triple bonds are higher priority than double bonds
Can distillation be used to separate enantiomers?
Enantiomers have the same boiling point so cannot be separated by distillation
Can chiral catalysts change the chirality of products?
Chiral catalysts can change the chirality of the product because the transition state is affected
When do ionization energy exceptions occur?
Ionization energy exceptions occur when there is a half-filled stability of the energy level and when there is an s2-shell
What sub-shell numbers correspond to l=1?
Electrons in the l=1 sub-level can only have -1, 0, or 1 sub-shell numbers
What are paramagnetic species?
Paramagnetic species have an unpaired electron, compounds including transition metal compounds can be paramagnetic
How do you find the number of d orbital electron in a transition metal in a compound?
To find the number of d orbital electrons determine the oxidation state of the transition metal and then use that to adjust from the number of electrons in ground state
Which electrons are removed first when transition metals are ionized?
Electrons are taken from the s orbital and then the d orbital
What is the equation for the work done by a gas?
For a gas, W = -P∆V
What is the relationship between work, heat, and energy in a refrigerator?
In a refrigerator work is added to the system and heat is removed (opposite of heat pump), Energy is conserved
What is the relationship between work, heat, and energy?
∆E - q + w, so when energy is conserved q and w are opposite signed
What happens when gas is compressed?
When gas is compressed heat is released
How many ATPs are produced in one round of glycolysis?
Glycolysis produces 2 ATP molecules per glucose
Where do leukocytes travel to?
Leukocytes move towards inflammation
How does glucose travel around the body?
The beating heart circulates blood that distributes glucose to tissues
What does the Hardy-Weinberg law say?
The frequency of carriers is given by 2pq
How do extrachromosomal genes get passed on?
Extrachromosomal genes that are passed on must-self replicate
What happens during meiosis of vertebrate oocytes?
When a vertebrate oocyte divides in meiosis most of the cytoplasm goes to the daughter cell destined to be the ovum and the other daughter cells, the polar bodies, are cast off with little cytoplasm
Does anaerobic respiration require energy input?
ATP must be consumed to kickstart anaerobic respiration
What are the organic components of human bone?
The human bone would be expected to contain calcium, phosphate and hydroxyl groups
Why can glutamine hydrogen bond with glutamate?
Glutamine’s NH2 group of the side chain can act as a hydrogen bond donor
How do uncompetitive inhibitors effect kinetic values like Km, Kcat, Vmax?
Uncompetitive inhibitors effect Km and Kcat but not Km/Vmax because they bind only to enzyme substrate complexes
What is specific activity?
Specific activity is a measure of the amount of enzyme per milligram of total protein; this provides a measure of the purity of an enzymatic mixture
What is the last to elute in size-exclusion chromatography?
In size-exclusion chromatography smallest molecules are the last to elute
What needs to be present to form disulfide bonds?
Disulfide bonds between two protein subunits require a reducing agent
What do good nucleophiles need?
Atoms with available lone pairs make good nucleophiles
When does glucose bind and release its symporter?
Glucose binds to the symporter in high extracellular Na+ concentrations and releases in low intracellular Na+ concentrations
What is the relationship between concentration gradient and movement of ions via simple diffusion?
As the concentration gradient increases the movement of ions through simple diffusion increases
What affect does the AcH receptor have on ion concentration in the cell?
AcH receptor directly allows more Na+ to enter the cell than K+ to leave the cell
When does the threshold potential occur in term of ion movement?
The threshold potential for an aciton potential is the point where the influx of Na+ exactly matches the efflux of K
What is the status of ion channels at the peak of an action potential?
When the action potential peaks, slow Na+ channels have closed but fast channels are still open, K+ channels are open
What enzyme removes a carboxylic acid?
A decarboxylase removes a carboxylic acid
What affect does sympathetic nerve stimulation have on pupil size?
Sympathetic nerve stimulation increases pupil size (dilates pupils)
What lenses are used to fix lens and cornea issues
Lens and cornea issues should be fixed with compatible non-uniform lenses that allow the image to focus on the retina
How do competitive inhibitors affect the maximum and half-maximum binding substrate concentrations?
Competitive inhibitors don’t change the maximum binding concentration because receptors are not changed but the half-maximum binding becomes higher because the receptor has less affinity for the substrate
What happens when a pathway stimulates both the parasympathetic and sympathetic nervous system
When a pathway stimulates both the parasympathetic and sympathetic nervous system one may be dominant causing stress
How do the lengths of fibers compare in the sympathetic nervous system?
Preganglionic fibers are short while postganglionic fibers are long
Why do blood capillaries have lower velocity?
Capillaries have larger cross-sectional areas so lower average velocities because blood flow is velocity x cross sectional area
How do veinus pressure and arterial pressure change over the heart cycle?
Arterial pressure but not veinus pressure changes significantly over the heart cycle
What component of the circulatory system has a low percentage of blood?
Arterioles have the least blood volume in the circulatory system, veins have a much higher percentage of the blood than arteries
What happens to arterial and venous pressure and blood flow if the heart stops?
If the heart stops cardiac output is reduced to zero and the pressures in the venous and arterial systems equilibrate
What hormones affect blood volume directly?
Vasopressin and aldosterone directly increase blood volume
How are single unit fibers coupled in the smooth muscle?
In the smooth muscle single unit fibers are coupled through gap junctions
The channels of which ions are responsible for the speed of action potentials in smooth muscles?
Calcium is responsible for the conduction velocity of an action potential in smooth muscles
How does duodenum activity effect the gallbladder?
The duodenum secretes CCK and CCK stimulates gallbladder contraction
What do anti-acids do?
Anti-acids delay the appearance of acid in the stomach by neutralizing the increase in gastrointestinal acid caused by eating
What are trypsins?
Trypsins are secreted by the pancreas and activate digestive enzymes in the small intestine
What component of the intestine is responsible for fat droplet absorption?
Intestinal cell microvilli are responsible for the absorption of fat droplets
What is bile salt secretion needed for?
Bile sale secretion is needed for cholesterol absorption in the small intestine
What and where does lipoprotein lipase do?
Lipoprotein lipase cleaves the fatty acids from a molecule before it reaches the liver, cholesterol remains
What happens when the solute concentration increases in the glomerulus?
Filtration rate decreases in the glomerulus if the solute concentration gets too high
How is sodium transported back across the membrane during reabsorption in the proximal convoluted tubule?
Sodium is reabsorbed in the proximal convoluted tubule by symporters with glucose and amino acids
What is the relationship between afferent/efferent and artery/vein direction of movement?
Arteries align with afferent, veins align with efferent
What happens to resting potential if the bodily concentration of K+ is decreased?
If there is less K+ in a cell, the resting membrane potential will be more negative because there will be even less positive ions in the cell
What happens to enzymes if there is a hole in dialysis tubing
The enzyme will exit the tubing if there is a hole
What does the hormone erythropoietin do and what organ produces it?
Erythropoietin signals the bone marrow to make more red blood cells and is produced by the kidney
What is edema and what organ failure does it indicate?
Edema is the accumulation of fluid in the intercellular spaces leading to tissue swelling and indicates tissue failure
How are concentrations altered by dialysis tubing?
Small ions and water can move through dialysis tubing, concentration of larger molecules depends on the water movement
How does protein in the plasma affect osmotic force in Bowman’s capsule?
Protein in the plasma can’t be filtered to it creates an osmotic force that pulls fluid away from Bowman’s capsule
How does the body react to a decreased level of something?
The body acts to reverse a deficiency causing increased levels of what was decreased and its product
How do steroid hormones relay signals?
Steroid hormones like testosterone pass through the plasma membranes of cells, directly affecting DNA transcription
How does the humanistic perspective explain behavior?
In the humanistic perspective behavior is explained through self-concept and incongruence
What is locus of control?
Locus of control is belief about whether life events are due to own actions (internal) or due to outside forces beyond your control (external)
What is habituation?
Habituation is loss of response to a repeating stimuli
How do experiences shape people with functioning implicit memories?
Having implicit memory capabilities allows an individual to develop and and change responses based on experiences
What is validity in a sociology experiment?
Validity refers to the extent to which a measure reflects the phenomenon being studied
What is the relationship between education level and risk for health issues?
Greater educational attainment is often associated with less risk factors for health issues
Why does plating metals on carbon increase reactivity?
Plating a metal onto the surface of carbon maximizes surface area making reactivity most efficient
What gases can form after the cation is completely reduced in an electrolytic cell?
Once the cation is completely reduced, hydrogen and oxygen gas may form from electrolysis of water
How is electricity conducted in carbon complexes?
Deconjugated pi bonds in carbon complexes can conduct electricity
How does the sign and magnitidue of E_cell correspond to energy input needed?
A more negative E_cell requires more voltage input for electrolysis
What relationship between cathode and anode cation concentration yields higher a higher voltage?
Cells with higher ratios of cathode cation to anode cation have higher voltages (E_observed > E_cell)
How can the life of a Galvanic cell be increased?
Increasing cation concentration can increase the life of a Galvanic cell
When does E_observed = E_cell in a Galvanic cell?
When the anode and cathode cation concentrations are equal the E_observed = E_cell
How does the IR absorbance of an alkene double bond compare to that of a carbonyl?
Alkene IR absorbances are slightly lower than carbonyls because the carbonyl bond is slightly shorter/stronger
Can the hydrogen of an aldehyde can be split by hydrogens on the carbon on the other side of the carbonyl in hNMR?
The hydrogen of an aldehyde can be split by hydrogens on the carbon on the other side of the carbonyl
When is the secondary oocyte arrested?
The secondary oocyte is arrested in metaphase
What is the function of prostaglandins in reproduction?
Prostaglandins are known to regulate the female reproductive system, and are involved in the control of ovulation, the menstrual cycle and the induction of labour
What happens to progesterone levels when labor begins?
Progesterone is blocked when contractions are induced
What hormones maintain the corpus lutetium during menstruation and pregnancy?
LH maintains the corpus lutetium during luteal phase of menstruation and hCG secreted by the placenta maintains it during pregnancy
What organs produce estrogen and progesterone during pregnancy?
The placenta takes over estrogen and progesterone production from the ovaries after the first 6 weeks of pregnancy
What hormone and organ control the production of steroids during pregnancy?
The production of steroids during the early part of gestation is dependent on human chorionic gonadotropin (hCG) derived from the placenta
What ducts develop into the uterus and ejaculatory genitals?
Mullerian ducts develop into the uterus and Wolffian ducts develop into male genitals
When in gestation do sex based differences emerge?
Around week 6 of gestation the embryonic gonads become distinguishable by sex
What is the relationship between resistance and radius of a tube?
Resistance of a tube is inversely proportional to the radius to the the fourth power
How does estrogen cause relaxation?
Estrogen directly acts on vascular smooth muscle to cause relaxation
How does estrogen prevent coronary artery diseases?
Estrogen acts as a vasodilator and blocks vasoconstrictors
What hormone directly triggers ovulation?
Luteinizing hormone directly triggers ovulation
What organs produce and secrete oxytocin?
The hypothalamus produces oxytocin and sends it to the posterior pituitary where it is secreted
How can hormones be released without communicating with the bloodstream?
Hormones can be secreted from one cell to another without moving through the bloodstream
What do agonists do?
Agonists activate receptors and illicit a physiological response
Are spermatogonia haploid or diploid?
Spermatogonia are diploid cells
How are forces and centripetal force related in an oscillating pendulum?
In an oscillating pendulum, the sum of forces acting on the pendulum (tension minus gravity) is equal to the centripetal force
Are energy and momentum conserved in an oscillating pendulum?
Momentum and energy are not conserved because the external force of gravity is acting on the system and kinetic energy is constantly changing
What kind of neurotransmitters are most responsible for the perception of pain?
The neurotransmitters largely responsible for the perception of pain are endorphins (polypeptides produced in the brain)
Where is the concentration of a substance highest if it can move freely about the body?
If there are no significant barriers to a substances passage through the body its concentration will equilibrate around the body
What do phosphodiesterases do?
Phosphodiesterases break down ATP and cAMP
Does the brain have nociceptors?
The brain does not have nociceptors, making it insensitive to pain
What is a quasi-experimental design?
A quasi-experimental design systematically compares differences between groups that to which participants have not been randomly assigned
When is nonspecific immunity developed?
Nonspecific immunity develops from birth, prior to birth the placenta transfers antibodies
What kinds of bonds can be dissolved in high salt or high pH concentrations?
Weak bonds (hydrogen, van der waals, hydrophobic) can be dissolved in high salt and high pH concentrations, strong bonds (covalent) cannot
How does an antigen bind an antibody?
An epitope on the antigen binds a paratope on the antibody
What is a monovalent antigen?
A monovalent anitgen has affinity for only one epitope
How do cascades amplify products?
In biological cascades an enzyme acts on many molecules of the next step, amplifying the products
How is bone marrow involved in antibody production?
The bone marrow is the site of B-cell birth and maturation, B-cells are responsible for the production of antibodies
Where and by what is heme degraded?
Heme is degraded by bilirubin in the liver, spleen, and bone marrow
Where do polypeptide hormones act?
Polypeptide hormones act on receptors on the plasma membrane of a cell
How to insulin and EGF receptors convey messages within the cell?
EGF and insulin receptors use similar signal transduction mechanisms in that they both activate kinase cascades
What is the general pathway from secondary messengers to cellular response?
Secondary messengers often activate kinases/phosphatases which activate proteins which cause a cellular response
What is missing in individuals with type 1 diabetes?
In type 1 diabetes individuals do not have beta cells in the pancreas so they do not release insulin
What energetic cycle does insulin promote?
Insulin promotes glycolysis and the use of glucose as a source of fuel
What measures the kinetic energy of a gas?
Temperature is a measure of a gas’s kinetic energy, at the same temperature all gases have the same kinetic energy
What types of molecules deviate the most from the ideal gas law?
Molecules withe more intermolecular forces/more polar molecules and larger molecules deviate most from the ideal gas law
What equation relates pressure and force?
Pascal’s Principle: P=F/A
What happens in a container when pressure is unequal?
When pressure is unequal liquid will flow to the side of less pressure until equilibrium is reached
How does pressure change if density increases but force and area stay the same?
If force and area remain constant, pressure remains constant
What is the relationship between area and velocity in a tube? How does decreasing area affect pressure?
If the cross sectional area is smaller, fluid velocity will be larger (Av=k), this will make the pressure smaller (Bernoulli’s equation)
What kind of gas is best to propel through a has chromatography apparatus?
The best gas to propel through the gas chromatography apparatus is inert
Why does less of the more volatile liquid get removed as fractional distillation goes on?
As the distillation column heats up, there is less condensation so less of the more volatile liquid is removed
What state are most common amino acids in at physiological pH?
At physiological pH most of the common amino acids are in their zwitterionic form (amino group protonated and carboxyl group deprotonated)
What is the difference between hydration and hydroxylation?
Hydration is a complexation of water with another compound, hydroxylation adds a hydroxyl group to an organic compound
Why is a wide range of pKa values found within a protein?
Different R groups on amino acids have different pKas
How many molecules of water do you need to form an amide bond?
Formation of an amide bond for a polypeptide chain requires 1 molecule of water
What phase is S phase in?
S phase is a part of interphase
What types of cells don’t replicate?
Nerve cells and skeletal muscle cells do not replicate but remain in G1
What can autoradiography show?
Autoradiography can locate radioactively labeled molecules from radioactive decay of an isotope
Where is bacterial DNA located in the cell?
Bacterial DNA is in the cytoplasm, bacteria do not have nuclei!
Do rods or cones facilitate photopic or scotopic vision?
Cones facilitate photopic vision and rods facilitate scotopic vision
What is the relationship between interaural time difference and the distance the input travels to a coincidence detector?
The larger the ITF the farther that auditory input travels to reach a coincidence detector
What kind of information does the lateral geniculate nucleus process?
The lateral geniculate nucleus of the thalamus processes visual information from the contralateral field
Is competitive inhibition reversible or irreversible?
Competitive inhibition is reversible
What happens to a cell when no NET ATP is produced?
If ATP is not made, the cell stops growing
What does an uncoupling agent do?
An uncoupling agent prevents the phosphorylation of ADP to ATP
What happens in familial hypercholesterolemia
In FH LDL receptors don’t work so the cell increases LDL production and there is more LDL in the blood
How do ingested molecules end up in the bloodstream?
When molecules are digested they move into the bloodstream
What tissue stores the most glycogen?
Muscle has the most glycogen
What process converts pyruvate and alanine into glycogen?
Alanine and pyruvate become glycogen through gluconeogenesis
What is a transamination reaction?
Transamination is a reversible chemical reaction that transfers an amino group from an amino acid to an α-keto acid
What does a lower pKa say in terms of charge?
A lower pKa means the proton will be lost at a lower pH, and the molecule will be more negative
What is a monohybrid cross?
A monohybrid cross involves individuals that differ only with respect to the alleles at a single locus
What is the frequency of a homozygous dominant individual?
The prevalence of a homozygous dominant individual is p^2
Which bases are one member rings and which are two?
Purine rings (A,C) are two member, pyrimidine rings (G,T, U) are one member
Are bacterial DNA in the same packaging as eukaryotic DNA?
No, bacterial genomes are not packaged with histone proteins
What amino acid does AUG code for in eukaryotes and prokaryotes?
AUG is the start codon and encodes for methionine in eukaryotes and N-formylmethionine in prokaryotes
What is genetic drift?
Genetic drift is the change in frequency of an existing gene variant in the population due to random chance
Does the sense strand or the antisense strand give rise to functional RNA? Which one is identical to the functional RNA?
The antisense strand gives rise to functional RNA, which is nearly identical to the sense strand, the sense strand is not transcribed but contains the genetic code
Are base-paired strands oriented in the same or opposite directions?
Oposite- a 5’ to 3’ strand matches complementary to a 3’ to 5’ strand
What is tRNA?
tRNA is the amino acid carrier for protein translation
What equation can be used to determine the number of strands made in n cycles of DNA replication?
2x2^n
How do prokaryotes maintain genetic diversity?
Prokaryotes maintain genetic diversity through conjugation, transformation, transduction, and transposable elements
Are normally produced mRNA sense or antisense?
Normally produced mRNA are sense mRNA
What is hypoxia?
Hypoxia is when the body or a part of the body doesn’t have enough oxygen at the tissue level
What can cause diarrhea in terms of liquid uptake?
Increased movement of water from luminal epithelial cells to the intestinal lumen when something in the intestine can’t be digested can causes diarrhea
What is symport transport?
Symport refers to the transport of molecules in the same direction across the membrane
What are trans-acting genes?
Trans-acting genes are capable of activating on another chromosome
Is a molecule that is bound to DNA diffusible?
If a molecule is bound to DNA it is no longer diffusible
How does the fiber stay the same size when the muscle contracts?
Both ends of the microfilament are capped so that the fiber doesn’t change length as the muscle contracts
How do microfilaments elongate?
Microfilaments elongate by adding more actin monomers, most quickly to the + end
How does conjugation work?
In conjugation genes are transferred across a sexpilus from one bacteria to another
What is a stereotypes? Can it be about one’s own group?
Stereotype is an often unconscious categorization used to predict behavior, can be about one’s own group
What kind of input encodes for echoic memory?
Echoic memory is encoded by acoustic sensory information
What pairs of letters are most likely to be confused in the phonological loop?
Letters that sound the same (not look the same) are more likely to be confused in the phonological loop
What is lost and released in decarboxylation?
In decarboxylation the terminal carbon of a reactant is lost and carbon dioxide is released